atrophin-1 Antibody (C1): sc-517594

atrophin-1 Antibody (C1) is a mouse monoclonal IgG2b kappa light chain antibody that detects atrophin-1 protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). anti-atrophin-1 antibody (C1) is available as a non-conjugated format. atrophin-1, also known as dentatorubral-pallidoluysian atrophy protein, plays a crucial role in neuronal function and is involved in the regulation of gene expression and cellular signaling pathways. Proper functioning of atrophin-1 is vital for maintaining neuronal health, and disruptions in atrophin-1 activity can lead to severe neurodegenerative disorders. atrophin-1 is predominantly expressed in the ovary, testis, brain, and prostate, with additional presence in the thymus, liver, and leukocytes. Notably, defects in the ATN1 gene, which encodes atrophin-1, are linked to dentatorubral-pallidoluysian atrophy (DRPLA) and Haw River syndrome (HRS), both of which are dominant neurodegenerative disorders characterized by an expansion of polyglutamine repeats. The severity and onset of these conditions correlate with the number of repeats, with affected individuals exhibiting a range of symptoms including dementia, epilepsy, and cerebellar ataxia. atrophin-1 (C1) monoclonal antibody is an essential tool for researchers studying these complex diseases and the underlying mechanisms of neuronal degeneration.

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atrophin-1 Antibody (C1) References:

1. Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.  |  Schilling, G., et al. 1999. Neuron. 24: 275-86. PMID: 10677044
2. Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine.  |  Yanagisawa, H., et al. 2000. Hum Mol Genet. 9: 1433-42. PMID: 10814707
3. Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain.  |  Yazawa, I., et al. 1995. Nat Genet. 10: 99-103. PMID: 7647802
4. Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA).  |  Nagafuchi, S., et al. 1994. Nat Genet. 8: 177-82. PMID: 7842016
5. DRPLA gene (atrophin-1) sequence and mRNA expression in human brain.  |  Margolis, RL., et al. 1996. Brain Res Mol Brain Res. 36: 219-26. PMID: 8965642
6. Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis.  |  Miyashita, T., et al. 1997. J Biol Chem. 272: 29238-42. PMID: 9361003
7. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.  |  Wood, JD., et al. 1998. Mol Cell Neurosci. 11: 149-60. PMID: 9647693
8. Dentatorubral-pallidoluysian atrophy or Naito-Oyanagi disease.  |  Kanazawa, I. 1998. Neurogenetics. 2: 1-17. PMID: 9933295

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-atrophin-1 Antibody (C1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-atrophin-1 Antibody (C1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

atrophin-1 Antibody (C1) Specifications

Alternate Product Name: atrophin-1

Product Clone Name: C1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: atrophin-1

Epitope Species: human

Product Reactivity/Detection: atrophin-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 5% glycerol

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for atrophin-1 Antibody (C1): N/A