Molecular structure of Atosiban, CAS Number: 90779-69-4
Atosiban (CAS 90779-69-4)
Alternate Names:
1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
Application:
Atosiban is a peptide oxytocin receptor inhibitor
CAS Number:
90779-69-4
Purity:
≥98%
Molecular Weight:
994.19
Molecular Formula:
C43H67N11O12S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Atosiban is a peptide oxytocin receptor inhibitor. Atosiban is a synthetic peptide originating from oxytocin, a hormone naturally synthesized in the hypothalamus. It displays a diverse array of biological activities, explored through in vitro studies utilizing cell cultures. Atosiban exerts its effects by binding to the oxytocin receptor, a type of G-protein coupled receptor (GPCR). Upon binding, it triggers a signal transduction pathway, resulting in the inhibition of phospholipase C (PLC) enzyme activity.
Atosiban (CAS 90779-69-4) References
- Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials. | Coomarasamy, A., et al. 2003. BJOG. 110: 1045-9. PMID: 14664874
- Atosiban for preterm labour. | Tsatsaris, V., et al. 2004. Drugs. 64: 375-82. PMID: 14969573
- The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban. | Lyndrup, J. and Lamont, RF. 2007. Expert Opin Investig Drugs. 16: 843-53. PMID: 17501696
- Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation. | Wex, J., et al. 2009. BMC Pregnancy Childbirth. 9: 23. PMID: 19538754
- Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects. | Wex, J., et al. 2011. Eur J Obstet Gynecol Reprod Biol. 157: 128-35. PMID: 21620558
- Steroids, atosiban and pulmonary oedema: are or may be a cause? | Guy, J., et al. 2018. Int J Obstet Anesth. 34: 115. PMID: 29602690
- Safety and Efficacy of Tocolytics for the Treatment of Spontaneous Preterm Labour. | Lamont, RF. and Jørgensen, JS. 2019. Curr Pharm Des. 25: 577-592. PMID: 30931850
- Atosiban versus ritodrine as tocolytics in external cephalic version. | Couceiro Naveira, E. and López Ramón Y Cajal, C. 2022. J Matern Fetal Neonatal Med. 35: 80-85. PMID: 31931641
- Atosiban improves the outcome of embryo transfer. A systematic review and meta-analysis of randomized and non-randomized trials. | Schwarze, JE., et al. 2020. JBRA Assist Reprod. 24: 421-427. PMID: 32401462
- Usefulness of atosiban for tocolysis during external cephalic version: Systematic review and meta-analysis. | Riemma, G., et al. 2021. Eur J Obstet Gynecol Reprod Biol. 258: 86-92. PMID: 33421816
- Simulated Y-site compatibility of atosiban acetate with selected intravenous drugs. | Jiménez-Lozano, I., et al. 2022. Eur J Obstet Gynecol Reprod Biol. 275: 106-109. PMID: 35779331
- Tocolysis with nifedipine versus atosiban and perinatal outcome: an individual participant data meta-analysis. | van Winden, TMS., et al. 2022. BMC Pregnancy Childbirth. 22: 567. PMID: 35840927
- Hexoprenaline Compared with Atosiban as Tocolytic Treatment for Preterm Labor. | Kirchhoff, E., et al. 2022. Geburtshilfe Frauenheilkd. 82: 852-858. PMID: 35967742
Inhibitor of:
GALR2, MCH-2R, Oxytocin Receptor, Oxytocin-R, and TRH-R2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atosiban, 10 mg | sc-254947 | 10 mg | $200.00 | |||
Atosiban, 50 mg | sc-254947A | 50 mg | $305.00 | |||
Atosiban, 1 g | sc-254947B | 1 g | $4090.00 |