Molecular structure of Atorvastatin-d5 Lactone, CAS Number: 125995-03-1 (unlabeled)
Atorvastatin-d5 Lactone (CAS 1217749-86-4)
Application:
Atorvastatin-d5 Lactone is a labeled Atorvastatin intermediate
CAS Number:
1217749-86-4
Molecular Weight:
545.66
Molecular Formula:
C33H28D5FN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Atorvastatin-d5 Lactone is a modified version of atorvastatin lactone, where five hydrogen atoms are replaced by deuterium, a stable and non-radioactive isotope of hydrogen. This substitution alters the compound′s mass and physical properties slightly without significantly changing its chemical structure. Its primary use is in analytical chemistry, particularly in mass spectrometry and NMR spectroscopy. The incorporation of deuterium atoms provides distinct physical properties that are useful in these analytical techniques. It can be used in chemical studies to understand the behavior and properties of the parent compound, atorvastatin lactone, under different conditions.
Atorvastatin-d5 Lactone (CAS 1217749-86-4) References
- Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients. | Skottheim, IB., et al. 2009. Clin Pharmacol Ther. 86: 311-8. PMID: 19494810
- UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo. | Riedmaier, S., et al. 2010. Clin Pharmacol Ther. 87: 65-73. PMID: 19794410
- Atorvastatin metabolite measurements as a diagnostic tool for statin-induced myopathy. | Skottheim, IB., et al. 2011. Mol Diagn Ther. 15: 221-7. PMID: 21815705
- Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis. | Riedmaier, S., et al. 2011. Front Pharmacol. 2: 41. PMID: 21852972
Inhibitor of:
HMGCR, and MEK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atorvastatin-d5 Lactone, 1 mg | sc-217673 | 1 mg | $380.00 | |||
Atorvastatin-d5 Lactone, 1 mg | sc-217673-CW | 1 mg | $575.00 |