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Atorvastatin calcium salt trihydrate (CAS 344423-98-9)

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Application:
Atorvastatin calcium salt trihydrate is a specific inhibitor of HMGCR
CAS Number:
344423-98-9
Purity:
≥98%
Molecular Weight:
1209.38
Molecular Formula:
(C33H34FN2O5)2•Ca•3H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Atorvastatin calcium salt trihydrate is primarily used in biochemical research involving lipid metabolism. This compound aids in the study of enzyme inhibition, particularly focusing on enzymes involved in cholesterol synthesis pathways. Researchers utilize Atorvastatin calcium salt trihydrate to explore the regulatory mechanisms of lipid levels within cells, which contributes to broader understanding in metabolic studies. Additionally, this chemical is instrumental in investigations of gene expression related to lipid metabolism, providing insights into the genetic factors that influence enzyme activity.


Atorvastatin calcium salt trihydrate (CAS 344423-98-9) References

  1. Hypoxia/reoxygenation stress signals an increase in organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood-brain barrier: relevance to CNS drug delivery.  |  Thompson, BJ., et al. 2014. J Cereb Blood Flow Metab. 34: 699-707. PMID: 24473481
  2. Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium.  |  Herbet, M., et al. 2016. Exp Ther Med. 12: 3440-3444. PMID: 27882176
  3. CNOT2 Is Critically Involved in Atorvastatin Induced Apoptotic and Autophagic Cell Death in Non-Small Cell Lung Cancers.  |  Lee, J., et al. 2019. Cancers (Basel). 11: PMID: 31574980
  4. Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats.  |  Karbownik, A., et al. 2020. Pharmaceutics. 12: PMID: 32605304
  5. Anti-Proliferative Effect of Statins Is Mediated by DNMT1 Inhibition and p21 Expression in OSCC Cells.  |  Dongoran, RA., et al. 2020. Cancers (Basel). 12: PMID: 32731382
  6. Cholesterol synthesis disruption combined with a molecule-targeted drug is a promising metabolic therapy for EGFR mutant non-small cell lung cancer.  |  Luo, Y., et al. 2021. Transl Lung Cancer Res. 10: 128-142. PMID: 33569299
  7. Euphornin L promotes lipid clearance by dual regulation of LDLR and PCSK9.  |  Li, H., et al. 2021. Exp Ther Med. 22: 1381. PMID: 34650629
  8. Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection.  |  Malhi, M., et al. 2021. Commun Biol. 4: 1239. PMID: 34716403
  9. Metabolomic and Microbial Remodeling by Shanmei Capsule Improves Hyperlipidemia in High Fat Food-Induced Mice.  |  Du, L., et al. 2022. Front Cell Infect Microbiol. 12: 729940. PMID: 35573781
  10. StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells.  |  Yamane, J., et al. 2022. iScience. 25: 104538. PMID: 35754715
  11. Effects of Statin Combinations on Zika Virus Infection in Vero Cells.  |  Españo, E. and Kim, JK. 2022. Pharmaceutics. 15: PMID: 36678679
  12. Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes.  |  Kwon, J., et al. 2023. iScience. 26: 106161. PMID: 36895651
  13. Investigating potential anti-proliferative activity of different statins against five cancer cell lines.  |  Sarbassova, G., et al. 2023. Saudi Pharm J. 31: 727-735. PMID: 37181137

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Atorvastatin calcium salt trihydrate, 10 mg

sc-364723
10 mg
$143.00

Atorvastatin calcium salt trihydrate, 25 mg

sc-364723A
25 mg
$398.00

Atorvastatin calcium salt trihydrate, 100 mg

sc-364723B
100 mg
$648.00

Dear Sir/Madam, I want to know it's Atorvastatin calcium salt trihydrate, 5 mg sc-364723 soluble in Carboxylmetylcelulosa?

Asked by: Pt NC
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-04-07

Dear madams and sirs, we used to order Atorvastatin calcium salt with catalog number sc-217671. Which product has replaced that one? We want to repeat experiments with that Atorvastatin calcium salt. All the best  F. Zimmermann

Asked by: F Zimmermann
Thank you for your question. Unfortunately we are unable to offer this product at this time.
Answered by: Tech Service
Date published: 2020-03-13

what is the Formula Weight?

Asked by: RAAD
Formula weight is synonymous to molecular weight. The ratio of Atorvastatin:Calcium:Water is 1:0.5:1.5. Therefore, for one molecule of Atorvastatin the MW is 604.69. The formula and MW we advertise on our product page is for two molecules. The MW in this case is 1209.38.
Answered by: Technical Support
Date published: 2021-12-14

What is the solubility of this product in DMSO?

Asked by: hawkeye11
Thank you for your question. The solubility of this compound is 10 mg/ml in both DMSO and methanol, for a concentration of 100 mM. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-19
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Rated 3 out of 5 by from Atorvastatin calcium trihydrate USP = 250 kgDear sir, this product I will order to you up to 1 mounth, please send us your beneficiary price name, GMP, COA, source validation copy, stability data, and sample is approve order to you.
Date published: 2024-02-26
Rated 5 out of 5 by from ZemankovaZemankova, L. et al. (PubMed 26084222) reported that Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin. -SCBT Publication Review
Date published: 2015-05-30
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Atorvastatin calcium salt trihydrate is rated 4.0 out of 5 by 2.
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