Atorvastatin Acyl-β-D-glucuronide 70%, contains up to 30% lactone (CAS 463962-58-5)

Atorvastatin Acyl-β-D-glucuronide, a metabolite of atorvastatin, appears in its stable form, comprising approximately 70% of its composition, with up to 30% existing as the lactone form. This compound is of significant interest in biochemical research due to its interaction with enzymes involved in lipid metabolism. As a glucuronide conjugate, it plays a role in studies focused on the metabolism and elimination pathways of lipophilic molecules, acting as a key marker in the investigation of enzymatic processes within the liver. This metabolite is useful in the exploration of glucuronidation, a major phase II metabolic reaction where glucuronic acid is added to substances, enhancing their solubility and facilitating their excretion. The presence of both the glucuronide and lactone forms allows researchers to examine the dynamic equilibrium between these two states, providing insights into the stability and transformation of metabolites under various physiological conditions.