Molecular structure of Atorvastatin, CAS Number: 134523-00-5
Atorvastatin (CAS 134523-00-5)
See product citations (9)
Alternate Names:
Atorvastatin is known as an HMG-CoA reductase inhibitor.
Application:
Atorvastatin is a potent, selective and competitive HMG-CoA reductase inhibitor, with oral bioavailability.
CAS Number:
134523-00-5
Molecular Weight:
558.64
Molecular Formula:
C33H35FN2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Atorvastatin is an inhibitor of HMG-CoA reductase. In vivo, it reduces cholestorol synthesis. While increasing HDL cholesterol levels, Atorvastatin simultaneously lowers serum levels, as well as LDL choesterol, apoB, and triglyceride levels. It is a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis.
Atorvastatin (CAS 134523-00-5) References
- Effects of atorvastatin on chronic subdural hematoma: A systematic review. | Qiu, S., et al. 2017. Medicine (Baltimore). 96: e7290. PMID: 28658127
- Efficacy comparison of rosuvastatin and atorvastatin in the treatment of atherosclerosis and drug safety analysis. | Liping, Z., et al. 2018. Pak J Pharm Sci. 31: 2203-2208. PMID: 30463813
- Atorvastatin: A Review of Analytical Methods for Pharmaceutical Quality Control and Monitoring. | Kogawa, AC., et al. 2019. J AOAC Int. 102: 801-809. PMID: 30563586
- Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice. | Taniguti, EH., et al. 2019. Brain Res Bull. 146: 279-286. PMID: 30690060
- Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. | Chen, J., et al. 2021. Cell Cycle. 20: 2160-2173. PMID: 34494933
- Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver. | Hu, N., et al. 2021. Int J Mol Sci. 22: PMID: 34681767
- Impact of atorvastatin on erectile dysfunction: A meta-analysis and systematic review. | Su, H., et al. 2022. Andrologia. 54: e14408. PMID: 35224753
- Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p-CREB/BDNF pathway in hypoxic-ischemic neonatal rats. | Yu, L., et al. 2022. FASEB J. 36: e22263. PMID: 35303316
- Atorvastatin Inhibits Viability and Migration of MCF7 Breast Cancer Cells. | Abolghasemi, R., et al. 2022. Asian Pac J Cancer Prev. 23: 867-875. PMID: 35345358
- Atorvastatin Attenuates Radiotherapy-Induced Intestinal Damage through Activation of Autophagy and Antioxidant Effects. | Wei, MF., et al. 2022. Oxid Med Cell Longev. 2022: 7957255. PMID: 36092168
- A review of effects of atorvastatin in cancer therapy. | Shaghaghi, Z., et al. 2022. Med Oncol. 40: 27. PMID: 36459301
- Immunomodulatory effects of atorvastatin on MRL/lpr mice. | Sun, J., et al. 2022. Adv Rheumatol. 62: 47. PMID: 36471414
- Recurrence risk in symptomatic intracranial stenosis treated medically in the real world. | Yaghi, S., et al. 2023. J Stroke Cerebrovasc Dis. 32: 107086. PMID: 37030126
Inhibitor of:
2410076I21Rik, AADACL1, ABCG1, ABCG5, ABHD3, ACOT8, ACSVL3, Afamin, AI-BP, AMAC1L2, Angptl2, Angptl3, Angptl5, Angptl7, apoA-II, apoAL, apoB48R, APOC (Apolipoprotein C), apoC-III, apoC1, apoH, APOL (Apolipoprotein L), apoL-VI, apoO, APOP1, ARHGAP19, BBS9, BPIL1, C20orf79, CapZ-β, caveolin-2, CCDC132, CCM3, cHMGCS, Cholesterol Esterase, CIDE-B, cornifelin, CTRL, CYB5R1, DDHD1, DDHD2, DHDDS, Dnajc22, Dokl, DSCD75, DYSFIP1, EBPL, EG624219, EG625591, EG625716, EG666803, EG668114, Endothelial Lipase, EXD, FIT1, G3PP, GGPL-I, Gm13718, Gm14306, GNPAT, GP73, GRAMD1A, GRAMD1B, group IVE sPLA2, HMG-3, HMG-4, HMGCL, HMGCLL1, HMGCR, HRG-β3, Humanin, ICMT, IDI2, ILBP, INSIG-1, ITFG3, Kal1, KRIT1, Lamin A/C, LCAT, LDL, LDLRAD2, LDLRAD3, LIMP I, LIMP III, LIP1, LIPH, Lipid Biosynthesis, Lipin-2, LPAAT-δ, LPAAT-ε, LPAAT-ζ, LSR, Malcavernin, MARCH (membrane associated ring-CH-type finger), ME1, MENTHO, mHMGCS, MLYCD, Moesin, MtRPOL, MVD, MVK, Nir2, OAT3, OAT6, OATP-H, OATP-J, OATP1, OATP2A1, Olfr822, Olr211, Olr222, Olr255, Olr418, Olr806, OPLAH, ORP-8, osteocalcin, PAF acetylhydrolase 2, PDSS1, PDSS2, PDZ-RhoGEF, Peroxin 1, Peroxin 3, PGAP1, PKLR, Plb3, PON1, Raftlin-2, rcRPE, RIP15, SCD5, SCP-2, SCP2D1, SDPR, SDR16C6, SEC14L1, SEC14L2, SEC14L4, SgK223, SKI-1, SLC22A11, SLC22A14, SLC22A23, Slco6c1, Slco6d1, SOAT2, ST7, STARD, StARD10, StARD6, TERE1, TM7SF2, TTC39B, and ZDHHC7.Activator of:
AADACL2, ABO Blood Group Antigens, ACBD4, ACOT7, Adrenomedullin (ADM), AGTRAP, AKR1C6, apoA-IV, apoA-V, apoC-II, apoC-IV, apoF, ARL15, C20orf79, C22orf25, CD163L1, CD40, CES1, Ces3b, COQ5, CYP27A1, DHCR7, DPM1, EBFP, EBP, ELOVL1, EphA2, ephrin-A2, fetuin-A, FTα, GalNAc-T13, GCS-α-3, GDF-15, GGTase-Iβ, GRAMD1C, HRASLS, IFN-γRβ, INSIG-2, LAL, LDLR, LDLRAD4, Lewis Blood Group Antigen, Lmf1, LPL, MKP-4, MNS Blood Group Antigens, MYL7, NOSTRIN, NPAL2, NSDHL, OATP-A, OATP-E, OATP-J, Oatp2, Ox-LDL R-1, PC-PLD4, PC7/8, PIG-Q, PLTP, PMVK, Podocin, Prothrombin, SCARA5, SDR16C6, SEC14L3, SKI-1, SOCS-4, Sodium Taurochenodeoxycholate, SPFH1, SPPL3, Squalene epoxidase, SRCRB4D, SREBP-2, TBL2, TERE1, TFPI, Thrombin R, Thrombospondin 1, TMEM164, TMEM35, TRIM49, YFP, and ZNF202.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atorvastatin, 50 mg | sc-337542A | 50 mg | $257.00 | |||
Atorvastatin, 100 mg | sc-337542 | 100 mg | $505.00 |