Molecular structure of Atomoxetine-d3, Hydrochloride, CAS Number: 1217776-38-9
Atomoxetine-d3, Hydrochloride (CAS 1217776-38-9)
Application:
Atomoxetine-d3, Hydrochloride is a deuterium-labeled analog of Tomoxetine
CAS Number:
1217776-38-9
Molecular Weight:
294.83
Molecular Formula:
C17H18D3NO•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Atomoxetine-d3, Hydrochloride is a labeled analogue of Tomoxetine. Tomoxetine (Atomoxetine, LY 139603; sc-204349) is a competitve and specific inhibitor of norepinephrine reuptake while demonstrating weak serotonin and dopamine inhibition as studied in synaptosomes of rat hypothalamus. Additional studies indicate that this (-) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride; sc-211408). Additionally, in the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain.
Atomoxetine-d3, Hydrochloride (CAS 1217776-38-9) References
- Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. | Bymaster, FP., et al. 2002. Neuropsychopharmacology. 27: 699-711. PMID: 12431845
- Catecholamine influences on dorsolateral prefrontal cortical networks. | Arnsten, AF. 2011. Biol Psychiatry. 69: e89-99. PMID: 21489408
- Simultaneous quantification of 19 analytes in breast milk by liquid chromatography-tandem mass spectrometry (LC-MS/MS). | Monfort, A., et al. 2021. J Pharm Biomed Anal. 204: 114236. PMID: 34273657
- A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. | Wong, DT., et al. 1982. J Pharmacol Exp Ther. 222: 61-5. PMID: 6123593
- Determination of atomoxetine levels in human plasma using LC-MS/MS and clinical application to Chinese children with ADHD based on CPIC guidelines | Ying Xia, ORCID logo †a Hong-Li Guo, ORCID logo †a Ya-Hui Hu, ORCID logo a Jia-Yi Long,ab Jing Chen,c Feng Chen ORCID logo *a and Xing Ji ORCID logo *a. 2021. Analytical Methods. 13: 2434-2441.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atomoxetine-d3, Hydrochloride, 1 mg | sc-217670 | 1 mg | $360.00 | |||
| US: Only available in the US | ||||||