Atipamezole hydrochloride (CAS 104075-48-1)
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Atipamezole hydrochloride is a selective alpha2-adrenergic receptor antagonist in centrally and peripherally located neurons. Studies indicate that Atipamezole hydrochloride competitively antagonizes Clonidine hydrochloride (sc-203002) and medetomidine hydrochloride (sc-204073) at presynaptic alpha2-adrenoceptors. In addition, Atipamezole hydrochloride can partially effect the vasoconstrictor effects of activated by alpha1 receptors. Alternate studies show that alpha2-adrenergic receptor antagonists such as Atipamezole hydrochloride can inhibit the reduction of both spontaneous and electrically-evoked phasic contractions in samples of equine jejunum from horses via interfering with the ability of agonists to bind to the receptor. Furthermore, studies show that Atipamezole hydrochloride stimulates the release of aldosterone and inhibits the mitochondrial CYP (cytochrome P450). Atipamezole hydrochloride is an inhibitor of alpha2A-AR, alpha2B-AR and alpha2C-AR.
Atipamezole hydrochloride (CAS 104075-48-1) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Atipamezole hydrochloride, 10 mg | sc-291914 | 10 mg | $148.00 | |||
Atipamezole hydrochloride, 50 mg | sc-291914A | 50 mg | $609.00 |