ATG7 Antibody (B-9): sc-376212

ATG7 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ATG7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATG7 (B-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ATG7 plays a crucial role in the autophagy process, which is essential for cellular homeostasis and survival during nutrient deprivation. Located in the cytoplasm, ATG7 is involved in the conjugation of ATG5 to ATG12, a critical step in the formation of autophagosomes, which are membrane structures that engulf and degrade damaged organelles and proteins. This process not only helps in recycling cellular components but also plays a significant role in cellular response to stress and maintenance of cellular integrity. ATG7′s interaction with other autophagy-related proteins underscores its importance in regulating autophagy, making ATG7 a vital target for research in various diseases, including cancer and neurodegenerative disorders.

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ATG7 Antibody (B-9) References:

1. Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy.  |  Tanida, I., et al. 1999. Mol Biol Cell. 10: 1367-79. PMID: 10233150
2. m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.  |  Wang, X., et al. 2020. Autophagy. 16: 1221-1235. PMID: 31451060
3. atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity.  |  Wang, Y., et al. 2021. Circ Res. 129: e166-e182. PMID: 34384247
4. METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression.  |  Chen, X., et al. 2022. Ann Rheum Dis. 81: 87-99. PMID: 34706873
5. Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.  |  Yao, H., et al. 2023. Autophagy. 19: 1491-1511. PMID: 36300763
6. Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy.  |  Xu, Y., et al. 2024. Autophagy. 20: 1134-1146. PMID: 37999993
7. Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.  |  Scott, SV., et al. 1996. Proc Natl Acad Sci U S A. 93: 12304-8. PMID: 8901576
8. Structural and functional analyses of APG5, a gene involved in autophagy in yeast.  |  Kametaka, S., et al. 1996. Gene. 178: 139-43. PMID: 8921905
9. Nonclassical protein sorting to the yeast vacuole.  |  Klionsky, DJ. 1998. J Biol Chem. 273: 10807-10. PMID: 9556549
10. Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast.  |  Hammond, EM., et al. 1998. FEBS Lett. 425: 391-5. PMID: 9563500
11. A protein conjugation system essential for autophagy.  |  Mizushima, N., et al. 1998. Nature. 395: 395-8. PMID: 9759731
12. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy.  |  Mizushima, N., et al. 1998. J Biol Chem. 273: 33889-92. PMID: 9852036

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ATG7 Antibody (B-9) has 58 citations in a variety of scientific publications.

Primary antibodies like Anti-ATG7 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ATG7 Antibody (B-9) Specifications

Alternate Product Name: ATG7

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: ATG7

Epitope Species: human

Product Reactivity/Detection: ATG7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 58 citations in various scientific publications

Available Conjugates/Forms for ATG7 Antibody (B-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin