ATC0175 (CAS 510733-97-8)
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ATC0175 is a potent and selective inhibitor of the enzyme tyrosine-protein kinase Mer (MERTK), which plays a critical role in various cellular processes, including regulation of cell survival, migration, and differentiation. By targeting MERTK, ATC0175 effectively disrupts its signaling pathways, which are implicated in the modulation of immune responses and in the progression of certain types of cellular proliferation. In research applications, ATC0175 has been utilized as a tool to elucidate the complex biological mechanisms underlying MERTK′s involvement in these processes, offering insights into the potential modulation of immune responses and the study of cellular behaviors that are critical in various physiological and pathological states. Its ability to selectively inhibit MERTK makes it a valuable compound for in vitro and in vivo studies aimed at understanding the role of this kinase in cellular function and its potential as a target for modulating cellular activities in a broad range of conditions.
ATC0175 (CAS 510733-97-8) References
- Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. | Chaki, S., et al. 2005. J Pharmacol Exp Ther. 313: 831-9. PMID: 15677346
- Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation. | Semple, G., et al. 2009. Bioorg Med Chem Lett. 19: 6166-71. PMID: 19773162
- Prodepressive effect induced by microinjections of MCH into the dorsal raphe: time course, dose dependence, effects on anxiety-related behaviors, and reversion by nortriptyline. | Urbanavicius, J., et al. 2014. Behav Pharmacol. 25: 316-24. PMID: 25006977
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ATC0175, 10 mg | sc-252391 | 10 mg | $520.00 |