ATC 0065 (CAS 510732-84-0)

ATC 0065 emerges as a highly selective and potent antagonist targeting the melanin-concentrating hormone receptor 1 (MCH-1R), a pivotal receptor implicated in the regulation of energy balance and feeding behavior among other physiological processes. Its mechanism of action is distinguished by its ability to selectively inhibit MCH-1R, thereby modulating the signaling pathways that MCH-1R influences. This specificity is further underscored by its remarkable 96-fold selectivity for MCH-1R over its counterpart, MCH2, highlighting its targeted approach in research applications that necessitate precise modulation of the MCH signaling pathway. Beyond its primary target, ATC 0065 also exhibits affinity towards the serotonin receptors 5-HT1A and 5-HT2B, suggesting a broader scope of interaction with neurotransmitter systems. This multifaceted receptor affinity positions ATC 0065 as useful in neuroscientific research, particularly in studies exploring the complex interplay between neurotransmitters and their impact on behavior and physiological functions. Its unique profile not only facilitates the exploration of the MCH-1R′s role in various biological processes but also aids in dissecting the nuanced contributions of serotonin receptors in the broader neural communication network.