ATB-343 (CAS 1000700-26-4)
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Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with inflammatory and vasodilator modulating activity (1). Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, ibuprofen and diclofenac, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-343 is a hybrid molecule of the NSAID indomethacinan and an H2S donor. In rats, ATB-343 does not cause gastric damage or promote leukocyte adherence to vascular endothelium, effects which are observed with only indomethacin treatment (2). These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than only traditional NSAIDs.
ATB-343 (CAS 1000700-26-4) References
- Hydrogen sulfide-releasing anti-inflammatory drugs. | Wallace, JL. 2007. Trends Pharmacol Sci. 28: 501-5. PMID: 17884186
- Hydrogen sulfide-based therapies: focus on H2S releasing NSAIDs. | Fiorucci, S. and Santucci, L. 2011. Inflamm Allergy Drug Targets. 10: 133-40. PMID: 21275896
- Therapeutic application of hydrogen sulfide donors: the potential and challenges. | Wu, D., et al. 2016. Front Med. 10: 18-27. PMID: 26597301
- Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. | Kiriyama, M., et al. 1997. Br J Pharmacol. 122: 217-24. PMID: 9313928
- Regulation of Cataractogenesis in Cultured Bovine Lenses by ATB 343 | Leonce N Maffofou, Segewkal H SegewkalHeruye, Ya Fatou Njie-Mbye, Sunny E Ohia, Catherine A. Opere. 2019. THE FASEB JOURNAL. 33: 812.8-812.8.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ATB-343, 1 mg | sc-223785 | 1 mg | $34.00 | |||
ATB-343, 5 mg | sc-223785A | 5 mg | $152.00 |