Astemizole-d3 (CAS 1189961-39-4)
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Astemizole-d3 is a chemical compound of significant interest in scientific research and pharmaceutical development. Deuterium substitution in Astemizole-d3 involves the replacement of three hydrogen atoms with deuterium atoms, which are heavy isotopes of hydrogen. Deuterium labeling is employed in research to investigate drug metabolism, pharmacokinetics, and pharmacodynamics. Astemizole-d3 serves as useful for studying the metabolic fate and effects of astemizole in vivo. By incorporating deuterium atoms, researchers can trace the compound′s distribution, elimination, and interaction with various enzymes and receptors. Studies focusing on Astemizole-d3 aim to enhance our understanding of the pharmacokinetics and pharmacodynamics of astemizole. By utilizing this labeled compound, researchers can explore the impact of genetic factors, enzyme activity, and other variables on astemizole′s efficacy.
Astemizole-d3 (CAS 1189961-39-4) References
- Reversal of acquired resistance to doxorubicin in K562 human leukemia cells by astemizole. | Ishikawa, M., et al. 2000. Biol Pharm Bull. 23: 112-5. PMID: 10706423
- Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: the critical role of hEag1 channels in G1 phase progression. | Borowiec, AS., et al. 2011. Biochim Biophys Acta. 1813: 723-30. PMID: 21315112
- An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes - application to establishing CYP2C8 inhibitor selectivity. | Kahma, H., et al. 2021. Eur J Pharm Sci. 162: 105810. PMID: 33753217
- Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. | Suessbrich, H., et al. 1996. FEBS Lett. 385: 77-80. PMID: 8641472
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Astemizole-d3, 1 mg | sc-217667 | 1 mg | $533.00 |