Astemizole (CAS 68844-77-9)
See product citations (5)
QUICK LINKS
Astemizole is a compound that has been the subject of various research studies due to its interaction with histamine receptors and other biological targets. In scientific investigations, it is often used as a tool to probe the function of the histamine H1 receptor, helping to elucidate the complex signaling pathways associated with histamine response. Moreover, Astemizole is known for its ability to inhibit certain potassium channels, which has made it valuable in cardiac electrophysiology studies, where researchers aim to understand the ionic currents contributing to the cardiac action potential. Outside of its known histamine receptor affinity, Astemizole has also been utilized in studies exploring its potential impact on other cellular processes, including its off-target effects.
Astemizole (CAS 68844-77-9) References
- Reversal of acquired resistance to doxorubicin in K562 human leukemia cells by astemizole. | Ishikawa, M., et al. 2000. Biol Pharm Bull. 23: 112-5. PMID: 10706423
- The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations. | Ficker, E., et al. 2002. J Biol Chem. 277: 4989-98. PMID: 11741928
- A clinical drug library screen identifies astemizole as an antimalarial agent. | Chong, CR., et al. 2006. Nat Chem Biol. 2: 415-6. PMID: 16816845
- Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7. | Roy, J., et al. 2008. Oncol Rep. 19: 1511-6. PMID: 18497958
- Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum. | Wang, L., et al. 2009. Mol Pharmacol. 75: 927-37. PMID: 19139152
- Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds. | Tian, J., et al. 2017. Bioorg Med Chem. 25: 6332-6344. PMID: 29042223
- Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking. | Lyu, J., et al. 2018. Int J Biol Sci. 14: 1175-1185. PMID: 30123067
- Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel. | Zhang, X., et al. 2019. Medchemcomm. 10: 513-516. PMID: 31057730
- Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity. | Hasanovic, A., et al. 2020. Biomedicines. 8: PMID: 32751066
- Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole. | Asai, T., et al. 2021. Structure. 29: 203-212.e4. PMID: 33450182
- Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro. | Wang, X., et al. 2021. Microb Pathog. 156: 104929. PMID: 33932547
- In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole. | Laduron, PM., et al. 1982. Mol Pharmacol. 21: 294-300. PMID: 6124876
- Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy. | Richards, DM., et al. 1984. Drugs. 28: 38-61. PMID: 6204835
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Astemizole, 10 mg | sc-201088 | 10 mg | $113.00 | |||
Astemizole, 50 mg | sc-201088A | 50 mg | $404.00 |