Molecular structure of Aspirin, CAS Number: 50-78-2
Aspirin (CAS 50-78-2)
See product citations (4)
Alternate Names:
Acetylsalicylate; O-Acetylsalicylic acid
Application:
Aspirin is an inhibitor of COX-1 (cylooxygenase) and NFκB
CAS Number:
50-78-2
Purity:
≥99%
Molecular Weight:
180.16
Molecular Formula:
C9H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aspirin is extensively used in research focusing on its biochemical properties and mechanisms of action. This compound is of particular interest due to its ability to inhibit cyclooxygenase enzymes, which play a key role in the biosynthesis of prostaglandins and thromboxanes. Researchers utilize Aspirin in studies to understand the modulation of inflammatory pathways and its impact on cellular signaling processes. Additionally, Aspirin is employed in investigations related to its influence on platelet aggregation, which is for understanding blood clot formation at a biochemical level. Studies also explore the potential of Aspirin to affect the expression of genes involved in inflammation and cell cycle regulation, providing insights into its broader biological impacts.
Aspirin (CAS 50-78-2) References
- Anti-inflammatory effects of aspirin and sodium salicylate. | Amann, R. and Peskar, BA. 2002. Eur J Pharmacol. 447: 1-9. PMID: 12106797
- The role of aspirin-triggered lipoxins in the mechanism of action of aspirin. | Gilroy, DW. 2005. Prostaglandins Leukot Essent Fatty Acids. 73: 203-10. PMID: 15978791
- Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. | Iglesias-Serret, D., et al. 2010. Apoptosis. 15: 219-29. PMID: 19936928
- The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury. | Yeager, RA., et al. 1990. J Invest Surg. 3: 5-10. PMID: 2282348
- [Aspirin for secondary prevention of venous thromboembolism. WARFASA: far from being conclusive]. | Delluc, A., et al. 2013. Rev Med Interne. 34: 69-72. PMID: 23154111
- Complex roles of the old drug aspirin in cancer chemoprevention and therapy. | Hua, H., et al. 2019. Med Res Rev. 39: 114-145. PMID: 29855050
- Aspirin-inspired acetyl-donating HDACs inhibitors. | Lim, J., et al. 2018. Arch Pharm Res. 41: 967-976. PMID: 29922878
- Aspirin in Primary Prevention of Cardiovascular Events. | Soodi, D., et al. 2020. Clin Med Res. 18: 89-94. PMID: 32580960
- Mechanisms of Colorectal Cancer Prevention by Aspirin-A Literature Review and Perspective on the Role of COX-Dependent and -Independent Pathways. | Sankaranarayanan, R., et al. 2020. Int J Mol Sci. 21: PMID: 33260951
- Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function. | Myers, RA., et al. 2022. Br J Clin Pharmacol. 88: 2074-2083. PMID: 34705291
- Aspirin-Mediated Reset of Preeclamptic Placental Stem Cell Transcriptome - Implication for Stabilized Placental Function. | Romagano, MP., et al. 2022. Stem Cell Rev Rep. 18: 3066-3082. PMID: 35908144
- Prevention of pre-eclampsia with aspirin: A systematic review of guidelines and evaluation of the quality of recommendation evidence. | Ninan, K., et al. 2023. Int J Gynaecol Obstet. 161: 26-39. PMID: 36129381
- Inhibition of NF-kappa B by sodium salicylate and aspirin. | Kopp, E. and Ghosh, S. 1994. Science. 265: 956-9. PMID: 8052854
- Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. | Grilli, M., et al. 1996. Science. 274: 1383-5. PMID: 8910280
- The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. | Yin, MJ., et al. 1998. Nature. 396: 77-80. PMID: 9817203
Inhibitor of:
α-1-Microglobulin, α-actinin-1, α-defensin 1B, α-defensin 2, α-defensin 4, β thromboglobulin, β-defensin 116, β-defensin 121, β-defensin 123, β-defensin 124, β-defensin 125, β-defensin 130, β-defensin 136, β-defensin 4, β-defensin 6, 9530003J23Rik, AGP-2, AKR1C20, arginase II, ASC2, B23, Baff, BPIL1, BST-2, C10orf115, C11orf51, C12orf75, C18orf19, C19orf51, C3b, C4 A, C4BPαZ, Calcitriol, Calgranulin A, CapZ-β, CCL12, CCL15, CCL16, CD203a, CD21L, CD42b, Cd59b, CD62L ligand, CKR-2, CLEC-18B, COL4A1, COL9A3, Colorectal Adenocarcinoma Marker, Conglutinin, Cox-2, CREB3L3, CSAG3, CTL2, CTRL, CUL-1, CysLT1 Receptor, cytohesin-4, D11Wsu47e, DFNB59, Differentiated Endothelial Cell Marker, Doc 4, Elmo3, ENDOGL1, ENGase, Enzyme, ES, ESAM, Factor VIII, FcRH6, FIZ1, FN3KRP, GDF-15, GIF, GLOD5, GM-CSF, Gm11062, Gm13247, Gm14139, Gm14306, GPVI, Granulocyte Marker, Granulocytee Marker, GRO, group IVC sPLA2, H2-Dk, HCC-1, Histatin 2, HNP, HPV 18-E7, HPV16 E6, HRASLS, HRG-α, HRG-β1, Humanin, HYAL5, IFIT1L, IFN-α10, IFN-α11, IFN-αB, IFRG15, IgG λ light chain, Igkv3-4, IKK beta, IL-12, IL-12A p35, IL-12B p40, IL-15Rα, IL-17B, IL-17D, IL-18Rβ, IL-1F7, IL-1F8, IL-3β, IL-5R, IL-8RA, ITBA1, Laminin γ-2, LCE2B, LHFPL5, Lipocalin-8, LOC402377, LOC622307, LPLUNC1, LTB4DH, lymphotactin, LYVE-1, LZIP, Mast Cell, MCP-1, MDA-7, MFG-E8, MG, MHC class II DQ, MOXD1, MPST, MRGE, MtRPOL, NALP11, NF kappa B, NF-1B, NF-1X, NFKBIL1, NRF-1, Olfr378, Olfr74, Olfr740, Olfr741, Olfr742, Olfr744, Olfr745, Olfr746, OMG, OPLAH, OTTMUSG00000019145, PAF acetylhydrolase 2, PEBP2β, PEPCK-M, PF-4, PGAM2, PGD synthase, PGE synthase 2, PGI2 synthase, PGRP-Iα, PGS1, PhyA, PLP-Cγ, PLSCR2, PSG1, PT, PTG, RbAp46, REGIIIα, SAA3, SerpinA9, SerpinB1a, SerpinB9e, SerpinB9g, SIMP, Sm E, SP-D, SPRR4, SR-A, ST8Sia V, Stereocilin, SUDD, SVCT1, TARC, TCR α, TFPI, TGaseZ, TMC2, TMEM174, TNF-IP 8L1, TNFα-IP 1, Tom1L-1, tPA, Trap1a, TREML1, TREML2, Tryptase ε, UGRP1, VWF, and Wnt-4.Activator of:
κB-Ras1, 15-LO, 15-LO2, 2310038E17Rik, Abin-1, Abin-2, ABO Blood Group Antigens, AKR1C19, AKR7A4, Annexin II, apoH, Asporin, BAF57, BAT4, BC030396, Blr1, Brucella abortus LPS, C1INH, C1qL4, cadherin-8, CagA, CCL23, CD163L1, CD200R2, CD35_Curry, CD42d, CMTM3, COX11, CRIP1, CTLA-4, CyPA, CysLT1, CysLT1 Receptor, DD2, dinitrophenol, DP, DP2_CRTH2, ECE-2, EPX, Fc γ RIIb, ficolin A, FSTL5, Glyoxalase I, GRB10, GROα, HHV-8 K-bZIP, Hydrocortisone, IκB-β, IκB-ε, ICAM-2, IFI-202, IFN-τ, IgG4, IKIP, IKK-i, IL-11Rα, IL-11Rα2, IL-12Rβ1, IL-1F5, IL-1F9, IL-1R8, IL-1RII, IL-23R, IL-32, IL-3R, IL-5R, IL-8RB, ILT-3, ILT-6, Intelectin-2, JTV1, karyopherin β2B, KBP, Kininogen II, KLRF1, LBP, LBP1, Lewis Blood Group Antigen, LOC100040214, LOC100041367, Ly-6C, MAdCAM-1, Mast Cell Protease 5, MCM7, MCP-3, MIP-2, MIP-3β, MKP-1, MNS Blood Group Antigens, MSLNL, NALP7, Neutrophil Marker, NFκB p50, NFKBIL2, NKp44, NLRC5, Nlrp12, NMT2, NOSTRIN, OAT5, OSTM1, PD-L2, Pepsin C, PGI2 synthase, Placental lactogen I, plasminogen, PLGLB1, PLGLB2, Protein C, PSG, Psg23, Psg25, Psg26, Ptx3, Raly, RELL1, RT1-B, SerpinA1f, SerpinA3a, SerpinA3b, SerpinA3g, SerpinB11, SIGIRR, Siglec-8, SLAM, SLC22A12, SLPI, SP140, T-kininogen 1, TAB182, TAFI, TANK, TFPI-2, Tim17B, TL, TNFα-IP 2, TNFα-IP 8, Tnfrsf26, TREML4, TROY, Tryptase ε, TXA synthase, UBE2E1, VHL, XYLB, ZG16, and ZNF207.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aspirin, 5 g | sc-202471 | 5 g | $20.00 | |||
Aspirin, 50 g | sc-202471A | 50 g | $41.00 |