Aspartoacylase Antibody (D-11): sc-377308

Aspartoacylase Antibody (D-11) is a mouse monoclonal IgM antibody that detects Aspartoacylase of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Aspartoacylase antibody (D-11) is available as the non-conjugated form. Aspartoacylase, also known as ASPA, ACY2, or ASP, is a 313 amino acid protein predominantly expressed in liver, lung, kidney, skeletal muscle, and cerebral white matter. Aspartoacylase exists as a homodimer and plays a critical role in the central nervous system by catalyzing the deacetylation of N-acetylaspartic acid (NAA) into acetate and L-aspartate, a process essential for maintaining white matter integrity. Proper functioning of Aspartoacylase is vital, as defects in the gene encoding this enzyme lead to Canavan disease, a rare neurodegenerative disorder characterized by severe neurological deficits, including hypotonia, atonia of neck muscles, and cognitive impairments. NAA accumulation due to impaired Aspartoacylase activity results in white matter vacuolization and demyelination, ultimately causing spongy degeneration of brain tissue. Aspartoacylase monoclonal antibody (D-11) serves as an invaluable tool for researchers studying molecular mechanisms underlying Canavan disease and related disorders, providing insights into potential therapeutic targets and strategies.

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Aspartoacylase Antibody (D-11) References:

1. Two novel aspartoacylase gene (ASPA) missense mutations specific to Norwegian and Swedish patients with Canavan disease.  |  Olsen, TR., et al. 2002. J Med Genet. 39: e55. PMID: 12205125
2. Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease.  |  Le Coq, J., et al. 2006. Biochemistry. 45: 5878-84. PMID: 16669630
3. Aspartoacylase is a regulated nuclear-cytoplasmic enzyme.  |  Hershfield, JR., et al. 2006. FASEB J. 20: 2139-41. PMID: 16935940
4. Structure of aspartoacylase, the brain enzyme impaired in Canavan disease.  |  Bitto, E., et al. 2007. Proc Natl Acad Sci U S A. 104: 456-61. PMID: 17194761
5. Mutational analysis of aspartoacylase: implications for Canavan disease.  |  Hershfield, JR., et al. 2007. Brain Res. 1148: 1-14. PMID: 17391648
6. Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue.  |  Le Coq, J., et al. 2008. Biochemistry. 47: 3484-92. PMID: 18293939
7. Canavan disease: mutations among Jewish and non-Jewish patients.  |  Kaul, R., et al. 1994. Am J Hum Genet. 55: 34-41. PMID: 8023850
8. Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease.  |  Kaul, R., et al. 1993. Nat Genet. 5: 118-23. PMID: 8252036

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aspartoacylase Antibody (D-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Aspartoacylase Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aspartoacylase Antibody (D-11) Specifications

Alternate Product Name: Aspartoacylase

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 241-270

Epitope Target: Aspartoacylase

Epitope Species: human

Product Reactivity/Detection: Aspartoacylase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Aspartoacylase Antibody (D-11): P: Blocking Peptide