Asparaginase (CAS 9015-68-3)
Alternate Names:
L-asparaginase; L-Asparagine Amidohydrolase
CAS Number:
9015-68-3
Purity:
≥98%
Molecular Weight:
31731.9
Molecular Formula:
C1377H2208N382O442S17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Asparaginase is an essential enzyme responsible for facilitating the hydrolysis of asparagine into aspartic acid and ammonia. It plays a pivotal role in amino acid metabolism and can be found across a wide range of organisms including bacteria, fungi, plants, and animals. The enzyme serves as useful in examining amino acid and macromolecule metabolism, generating therapeutic proteins, and aiding in the diagnosis and treatment of various diseases.
Asparaginase (CAS 9015-68-3) References
- Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study. | Mitchell, L., et al. 2003. Thromb Haemost. 90: 235-44. PMID: 12888870
- Influence of two different regimens of concomitant treatment with asparaginase and dexamethasone on hemostasis in childhood acute lymphoblastic leukemia. | Appel, IM., et al. 2007. Leukemia. 21: 2377-80. PMID: 17554375
- L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer. | Yu, M., et al. 2012. J Cell Mol Med. 16: 2369-78. PMID: 22333033
- Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. | Nomme, J., et al. 2012. Biochemistry. 51: 6816-26. PMID: 22861376
- L-asparaginase induces in AML U937 cells apoptosis via an AIF-mediated mechanism. | He, Y., et al. 2014. Front Biosci (Landmark Ed). 19: 515-27. PMID: 24389199
- Albumin/asparaginase capsules prepared by ultrasound to retain ammonia. | Tinoco, A., et al. 2016. Appl Microbiol Biotechnol. 100: 9499-9508. PMID: 27314846
- Asparaginase inhibits the lectin pathway of complement activation. | Keizer, MP., et al. 2018. Mol Immunol. 93: 189-192. PMID: 29197742
- Leishmania donovani asparaginase variants exhibit cytosolic localization. | Tiwari, K. and Dubey, VK. 2018. Int J Biol Macromol. 114: 35-39. PMID: 29551509
- Asparaginase immune complexes induce Fc-γRIII-dependent hypersensitivity in naive mice. | Rathod, S., et al. 2019. FASEB J. 33: 10996-11005. PMID: 31284767
- The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia. | Cremer, P., et al. 1988. Eur J Pediatr. 147: 64-7. PMID: 3422190
- Plant asparaginase versus microbial asparaginase as anticancer agent. | Al-Hazmi, NE. and Naguib, DM. 2022. Environ Sci Pollut Res Int. 29: 27283-27293. PMID: 34978032
- Biomimetic lipidic nanovectors for effective asparaginase supramolecule delivery. | Wu, Y., et al. 2022. Nanomedicine. 41: 102518. PMID: 35032628
- Insights into Asparaginase from Endophytic Fungus Lasiodiplodia theobromae: Purification, Characterization and Antileukemic Activity. | Moubasher, HA., et al. 2022. Int J Environ Res Public Health. 19: PMID: 35055502
- The evolution and role of the periplasmic asparaginase Asp3 in yeast. | Coral-Medina, A., et al. 2022. FEMS Yeast Res. 22: PMID: 36040324
- Asparaginase activity monitoring in pediatric acute lymphoblastic leukemia: A cross-sectional nationwide study in Spain. | Lassaletta, Á., et al. 2023. Cancer Rep (Hoboken). 6: e1729. PMID: 36307379
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Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Asparaginase, 1 mg | sc-470689 | 1 mg | $79.00 | |||
Asparaginase, 5 mg | sc-470689A | 5 mg | $195.00 | |||
Asparaginase, 25 mg | sc-470689B | 25 mg | $546.00 | |||
Asparaginase, 400 mg | sc-470689C | 400 mg | $6300.00 |