ASB-C7BzO is a zwitterionic detergent which contains hydroxypropyl group between alkylphenyl hydrophobic tail and ammonio-propane sulfone hydrophilic head. Useful for solubilizing and stabilizing integral membrane proteins by disrupting aggregates. ASB-C7BzO is reported to be compatible with urea (~7 M) and has been used successfully to extract A. thaliana leaf plasma membrane proteins and band III, a 100 kDa erythrocyte polytransmembrane protein, by two-dimensional electrophoresis (2-DGE).
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3. Luche, Sylvie., et al., 2003. Evaluation of nonionic and zwitterionic detergents as membrane protein solubilizers in two-dimensional electrophoresis. Proteomics. 3(3): 249-53. PMID: 12627377
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