Molecular structure of AS 1269574, CAS Number: 330981-72-1
AS 1269574 (CAS 330981-72-1)
Alternate Names:
2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol
Application:
AS 1269574 is A GPR119 receptor agonist
CAS Number:
330981-72-1
Molecular Weight:
308.17
Molecular Formula:
C13H14BrN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AS 1269574 is a GPR119 receptor agonist.
AS 1269574 (CAS 330981-72-1) References
- Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. | Yoshida, S., et al. 2010. Biochem Biophys Res Commun. 400: 437-41. PMID: 20804735
- AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. | Yoshida, S., et al. 2010. Biochem Biophys Res Commun. 400: 745-51. PMID: 20816753
- Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice. | Yoshida, S., et al. 2010. Biochem Biophys Res Commun. 402: 280-5. PMID: 20937249
- Novel GPR119 agonist AS1669058 potentiates insulin secretion from rat islets and has potent anti-diabetic effects in ICR and diabetic db/db mice. | Oshima, H., et al. 2013. Life Sci. 92: 167-73. PMID: 23246743
- Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag. | Chepurny, OG., et al. 2013. Mol Endocrinol. 27: 1267-82. PMID: 23798572
- GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. | Chepurny, OG., et al. 2016. Mol Endocrinol. 30: 614-29. PMID: 27082897
- Therapeutic application of GPR119 ligands in metabolic disorders. | Yang, JW., et al. 2018. Diabetes Obes Metab. 20: 257-269. PMID: 28722242
- Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. | Irving, A., et al. 2017. Adv Pharmacol. 80: 223-247. PMID: 28826536
- G protein-coupled receptor 119 is involved in RANKL-induced osteoclast differentiation and fusion. | Kim, HJ., et al. 2019. J Cell Physiol. 234: 11490-11499. PMID: 30478996
- New Insights in Cannabinoid Receptor Structure and Signaling. | Ye, L., et al. 2019. Curr Mol Pharmacol. 12: 239-248. PMID: 30767756
- Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease. | Zhao, J., et al. 2021. Cell Mol Biol Lett. 26: 32. PMID: 34233623
- TRPA1: Pharmacology, natural activators and role in obesity prevention. | Mahajan, N., et al. 2021. Eur J Pharmacol. 912: 174553. PMID: 34627805
- GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats. | Zúñiga-Romero, Á., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35056124
- An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches. | Araújo, MC., et al. 2022. Cells. 11: PMID: 35455971
- Activation and signaling mechanism revealed by GPR119-Gs complex structures. | Qian, Y., et al. 2022. Nat Commun. 13: 7033. PMID: 36396650
Activator of:
GPR119.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AS 1269574, 10 mg | sc-361109 | 10 mg | $155.00 | |||
| US: Only available in the US | ||||||
AS 1269574, 50 mg | sc-361109A | 50 mg | $620.00 | |||
| US: Only available in the US | ||||||