Molecular structure of AS 101, CAS Number: 106566-58-9
AS 101 (CAS 106566-58-9)
See product citations (4)
Alternate Names:
Ammonium trichloro[1,2-ethanediolato-O,O′]-tellurate
Application:
AS 101 is an inhibitor of IL-10 synthesis
CAS Number:
106566-58-9
Molecular Weight:
312.05
Molecular Formula:
C2H4Cl3O2Te•NH4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
AS 101 is in scientific applications, particularly in studies focusing on its ability to modulate biological pathways involved in cellular regulation and immune responses. AS 101 is recognized for its role in influencing the production of cytokines, which are critical in controlling the behavior of immune cells. Some use AS 101 to investigate its effects on cytokine regulation, aiming to understand how this modulation impacts immune system functionality. AS 101 is utilized in studies related to oxidative stress, where it is examined for its potential to affect the oxidative environment within cells. The findings from these studies help identify the mechanisms through which AS 101 can influence cellular processes and immune responses, providing insights into its biological activities.
AS 101 (CAS 106566-58-9) References
- Inhibition of the reverse transcriptase activity and replication of human immunodeficiency virus type 1 by AS 101 in vitro. | Vonsover, A., et al. 1992. AIDS Res Hum Retroviruses. 8: 613-23. PMID: 1381205
- Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B. | Cunha, RL., et al. 2005. Bioorg Med Chem Lett. 15: 755-60. PMID: 15664852
- In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101. | Shohat, M., et al. 2005. Clin Exp Dermatol. 30: 432-4. PMID: 15953089
- Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. | Persike, DS., et al. 2008. Neurobiol Dis. 31: 120-6. PMID: 18571097
- A glimpse on biological activities of tellurium compounds. | Cunha, RL., et al. 2009. An Acad Bras Cienc. 81: 393-407. PMID: 19722011
- Gateways to clinical trials. | Tomillero, A. and Moral, MA. 2009. Methods Find Exp Clin Pharmacol. 31: 397-417. PMID: 19798455
- Effect of the new immunoregulator AS-101 on in vitro functions of mononuclear cells from patients with systemic lupus erythematosus. | Alcocer-Varela, J., et al. 1989. Clin Exp Immunol. 77: 319-23. PMID: 2530012
- Ligand-Substitution Reactions of the Tellurium Compound AS-101 in Physiological Aqueous and Alcoholic Solutions. | Silberman, A., et al. 2016. Inorg Chem. 55: 10847-10850. PMID: 27726342
- Investigation of Chemical Stability of Dihalogenated Organotelluranes in Organic-Aqueous Media: The Protagonism of Water. | Teixeira, ML., et al. 2018. J Org Chem. 83: 7341-7346. PMID: 29373033
- Stability of antibacterial Te(IV) compounds: A combined experimental and computational study. | D'Arcy, K., et al. 2019. J Inorg Biochem. 198: 110719. PMID: 31174178
- A new immunomodulating compound (AS-101) with potential therapeutic application. | Sredni, B., et al. Nature. 330: 173-6. PMID: 3118216
- The biological activity and immunotherapeutic properties of AS-101, a synthetic organotellurium compound. | Sredni, B., et al. 1988. Nat Immun Cell Growth Regul. 7: 163-8. PMID: 3262821
- Determination of tellurium in urine by isotope dilution gas chromatography/mass spectrometry using (4-fluorophenyl)magnesium bromide as a derivatizing agent and a comparison with electrothermal atomic absorption spectrometry. | Aggarwal, SK., et al. 1994. Anal Chem. 66: 1316-22. PMID: 8210046
- AS-101: a modulator of in vitro T-cell proliferation. | Montero, R., et al. 1993. Anticancer Drugs. 4: 351-4. PMID: 8358064
- The immunomodulator AS-101 inhibits IL-10 release and augments TNF alpha and IL-1 alpha release by mouse and human mononuclear phagocytes. | Strassmann, G., et al. 1997. Cell Immunol. 176: 180-5. PMID: 9073392
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AS 101, 10 mg | sc-203825 | 10 mg | $163.00 | |||
AS 101, 25 mg | sc-203825A | 25 mg | $587.00 |