ARX Antibody (4A8): sc-293449

ARX Antibody (4A8) is a mouse monoclonal IgG2b kappa light chain antibody that detects ARX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ARX antibody (4A8) is available as the non-conjugated form. The aristaless-related homeobox (ARX) gene encodes a protein consisting of 562 amino acids, featuring two conserved domains: a C-peptide (or aristaless domain) and a prd-like class homeobox domain. ARX monoclonal antibody (4A8) plays a crucial role in studying the differentiation and maintenance of neuronal cell types within the human central nervous system, making ARX essential for proper brain development and function. ARX (4A8) antibody helps detect expression predominantly in the fetal and adult brain as well as in skeletal muscle, highlighting ARX importance in both developmental and physiological contexts. Notably, defects in ARX are linked to a range of serious disorders, including X-linked mental retardation, X-linked lissencephaly with abnormal genitalia, and various epilepsy syndromes, underscoring ARX significance in neurodevelopmental processes. Anti-ARX antibody (4A8) can help researchers gain valuable insights into these conditions and the underlying mechanisms of neuronal differentiation and maintenance.

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ARX Antibody (4A8) References:

1. Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy.  |  Strømme, P., et al. 2002. Nat Genet. 30: 441-5. PMID: 11889467
2. Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.  |  Kitamura, K., et al. 2002. Nat Genet. 32: 359-69. PMID: 12379852
3. Arx homeobox gene is essential for development of mouse olfactory system.  |  Yoshihara, S., et al. 2005. Development. 132: 751-62. PMID: 15677725
4. Recombineered Xenopus tropicalis BAC expresses a GFP reporter under the control of Arx transcriptional regulatory elements in transgenic Xenopus laevis embryos.  |  Kelly, LE., et al. 2005. Genesis. 41: 185-91. PMID: 15789419
5. XLMR in MRX families 29, 32, 33 and 38 results from the dup24 mutation in the ARX (Aristaless related homeobox) gene.  |  Stepp, ML., et al. 2005. BMC Med Genet. 6: 16. PMID: 15850492
6. The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.  |  Collombat, P., et al. 2005. Development. 132: 2969-80. PMID: 15930104
7. Maternal mosaicism for mutations in the ARX gene in a family with X linked mental retardation.  |  Poirier, K., et al. 2005. Hum Genet. 118: 45-8. PMID: 16078051
8. Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms.  |  Olivetti, PR. and Noebels, JL. 2012. Curr Opin Neurobiol. 22: 859-65. PMID: 22565167
9. Present status and expectation of aristaless-related homeobox (ARX) in endocrine pancreas.  |  Xu, S. and Xu, JP. 2019. Int J Dev Biol. 63: 579-587. PMID: 32149367
10. Further Delineation of Duplications of ARX Locus Detected in Male Patients with Varying Degrees of Intellectual Disability.  |  Poeta, L., et al. 2022. Int J Mol Sci. 23: PMID: 35328505
11. Further characterisation of ARX-related disorders in females due to inherited or de novo variants.  |  Gras, M., et al. 2024. J Med Genet. 61: 103-108. PMID: 37879892
12. The spectrum of movement disorders in young children with ARX-related epilepsy-dyskinesia syndrome.  |  Akula, SK., et al. 2024. Ann Clin Transl Neurol. 11: 1643-1647. PMID: 38711225

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARX Antibody (4A8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-ARX Antibody (4A8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARX Antibody (4A8) Specifications

Alternate Product Name: ARX

Product Clone Name: 4A8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 159-264

Epitope Target: ARX

Epitope Species: human

Product Reactivity/Detection: ARX

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for ARX Antibody (4A8): N/A