Artn Antibody (BQ-74X): sc-73715

Artn Antibody (BQ-74X) is a rat monoclonal IgG2a antibody that detects the Artn protein of mouse origin by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Artn antibody (BQ-74X) is available as a non-conjugated format. Artemin (Artn) plays a crucial role in the development and maintenance of the nervous system, particularly in supporting the survival of both peripheral and central neurons. Artn (BQ-74X) antibody recognizes a member of the glial cell line-derived neurotrophic factor (GDNF) family, which includes other neurotrophic factors such as neurturin and persephin. Unlike GDNF and neurturin, which primarily support dopaminergic neurons, Artn has a broader range of action, promoting the survival of various neuronal types. The interaction of Artn with the GFRα-3-Ret receptor complex enhances neuronal survival and function, making Artn essential for neuroprotection. Artn can also interact with the GFRα-1-Ret receptor complex, which is the preferred receptor for GDNF, highlighting Artn′s versatility in signaling pathways. This multifaceted role in neuronal health underscores Artn′s importance in neurobiology and potential therapeutic applications in neurodegenerative diseases.

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Artn Antibody (BQ-74X) References:

1. Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells.  |  Hezam, K., et al. 2018. Rev Neurosci. 29: 93-98. PMID: 28937965
2. The role of glial cell line-derived neurotrophic factor family member artemin in neurological disorders and cancers.  |  Zhu, S., et al. 2020. Cell Prolif. 53: e12860. PMID: 32573073
3. Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling.  |  Zhu, M., et al. 2022. J Oncol. 2022: 3332485. PMID: 36471885
4. Expression of Glial-Cell-Line-Derived Neurotrophic Factor Family Ligands in Human Intervertebral Discs.  |  Iwasaki, T., et al. 2023. Int J Mol Sci. 24: PMID: 37958856
5. ARTN-GFRA3 axis induces epithelial-mesenchymal transition phenotypes, migration, and invasion of gastric cancer cells via KRAS signaling.  |  Wang, XL., et al. 2024. Neoplasma. 71: 266-278. PMID: 38958711
6. Modified Activation-Relaxation Technique (ARTn) Method Tuned for Efficient Identification of Transition States in Surface Reactions.  |  Jung, J., et al. 2024. J Chem Theory Comput.. PMID: 39240127
7. GDNF is an age-specific survival factor for sensory and autonomic neurons.  |  Buj-Bello, A., et al. 1995. Neuron. 15: 821-8. PMID: 7576631
8. Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia.  |  Ebendal, T., et al. 1995. J Neurosci Res. 40: 276-84. PMID: 7745621
9. Recent progress in studies of neurotrophic factors and their clinical implications.  |  Shen, L., et al. 1997. J Mol Med (Berl). 75: 637-44. PMID: 9351702
10. Persephin, a novel neurotrophic factor related to GDNF and neurturin.  |  Milbrandt, J., et al. 1998. Neuron. 20: 245-53. PMID: 9491986
11. III. Role Of the RET signal transduction pathway in development of the mammalian enteric nervous system.  |  Pachnis, V., et al. 1998. Am J Physiol. 275: G183-6. PMID: 9688643
12. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.  |  Baloh, RH., et al. 1998. Neuron. 21: 1291-302. PMID: 9883723

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Artn Antibody (BQ-74X) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Artn Antibody (BQ-74X) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Artn Antibody (BQ-74X) Specifications

Alternate Product Name: Artn

Product Clone Name: BQ-74X

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Artn

Epitope Species: mouse

Product Reactivity/Detection: Artn

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG_2a in 0.5 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Artn Antibody (BQ-74X): N/A