Molecular structure of Artemether, CAS Number: 71963-77-4
Artemether (CAS 71963-77-4)
See product citations (5)
CAS Number:
71963-77-4
Purity:
≥98%
Molecular Weight:
298.376
Molecular Formula:
C16H26O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Artemether is a chemical compound that functions as an antimalarial agent. It acts by inhibiting the growth and reproduction of the malaria parasite within the red blood cells. The mechanism of action involves the disruption of the parasite′s ability to form hemozoin, a toxic byproduct of hemoglobin digestion. This interference ultimately leads to the accumulation of toxic heme molecules, causing damage to the parasite and leading to its death. Artemether′s mode of action at the molecular level involves binding to heme and preventing its detoxification, resulting in oxidative damage and ultimately the destruction of the parasite.
Artemether (CAS 71963-77-4) References
- Artesunate, artemether or quinine in severe Plasmodium falciparum malaria? | Checkley, AM. and Whitty, CJ. 2007. Expert Rev Anti Infect Ther. 5: 199-204. PMID: 17402835
- Artemether Does Not Turn α Cells into β Cells. | van der Meulen, T., et al. 2018. Cell Metab. 27: 218-225.e4. PMID: 29103923
- Mechanisms of artemether toxicity on single cardiomyocytes and protective effect of nanoencapsulation. | Moreira Souza, AC., et al. 2020. Br J Pharmacol. 177: 4448-4463. PMID: 32608017
- Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway. | Li, Y., et al. 2020. Free Radic Biol Med. 160: 845-859. PMID: 32947011
- Artemether ameliorates kidney injury by restoring redox imbalance and improving mitochondrial function in Adriamycin nephropathy in mice. | Han, P., et al. 2021. Sci Rep. 11: 1266. PMID: 33446820
- Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii. | Volpe-Zanutto, F., et al. 2021. J Control Release. 333: 298-315. PMID: 33794272
- Artemether confers neuroprotection on cerebral ischemic injury through stimulation of the Erk1/2-P90rsk-CREB signaling pathway. | Li, S., et al. 2021. Redox Biol. 46: 102069. PMID: 34303216
- Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses In Vitro. | Hu, Y., et al. 2021. Front Cell Infect Microbiol. 11: 680127. PMID: 34527599
- Artemether and aspterric acid induce pancreatic alpha cells to transdifferentiate into beta cells in zebrafish. | Jia, J., et al. 2022. Br J Pharmacol. 179: 1962-1977. PMID: 34871457
- Preparation and application of a specific single-chain variable fragment against artemether. | Lu, F., et al. 2022. J Pharm Biomed Anal. 220: 115020. PMID: 36049377
- Artemether-loaded polymeric lipid-core nanocapsules reduce cell viability and alter the antioxidant status of U-87 MG cells. | Pires, J., et al. 2022. Pharm Dev Technol. 27: 892-903. PMID: 36168940
- Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient GluCreERT2;ROSA26-eYFP diabetic mice. | Sarnobat, D., et al. 2022. J Pharm Pharmacol. 74: 1758-1764. PMID: 36206181
- Artemether treatment improves islet function and metabolic homeostasis in diabetic nonhuman primates. | Fu, W., et al. 2023. J Diabetes. 15: 76-80. PMID: 36623941
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Artemether, 5 g | sc-291911 | 5 g | $62.00 | |||
Artemether, 25 g | sc-291911A | 25 g | $230.00 | |||
Artemether, 100 g | sc-291911B | 100 g | $765.00 | |||
Artemether, 1 kg | sc-291911C | 1 kg | $2040.00 | |||
Artemether, 10 kg | sc-291911D | 10 kg | $18360.00 |