Molecular structure of ARP 101, CAS Number: 849773-64-4
ARP 101 (CAS 849773-64-4)
See product citations (2)
Application:
ARP 101 is an inhibitor of metalloproteinase-2 (MMP-2)
CAS Number:
849773-64-4
Molecular Weight:
406.50
Molecular Formula:
C20H26N2O5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ARP 101 is a selective inhibitor of MMP-2 (metalloproteinase-2) and, to a lesser extent, MMP-9 (metalloproteinase-9), both of which have been shown to play a role in certain key functions of tumour cells, facilitating metastatic tumour dispersion and angiogenesis, resistance to apoptosis, and actication of EGF receptors. Studies of ARP 101 show in vitro inhibition of HT1080 sarcoma cell growth on matrigel. ARP 101 has shown ~250 fold selectivity of MMP-2 over MMP-1 and ~100 fold of MMP-9 over MMP-1.
ARP 101 (CAS 849773-64-4) References
- Matrix metalloproteinase inhibitors and cancer: trials and tribulations. | Coussens, LM., et al. 2002. Science. 295: 2387-92. PMID: 11923519
- New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). | Rossello, A., et al. 2004. Bioorg Med Chem. 12: 2441-50. PMID: 15080939
- Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. | Tuccinardi, T., et al. 2006. Bioorg Med Chem. 14: 4260-76. PMID: 16483784
- Matrix metalloproteinases and the regulation of tissue remodelling. | Page-McCaw, A., et al. 2007. Nat Rev Mol Cell Biol. 8: 221-33. PMID: 17318226
- ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. | Jo, YK., et al. 2011. Biochem Biophys Res Commun. 404: 1039-43. PMID: 21187062
- ARP101 inhibits α-MSH-stimulated melanogenesis by regulation of autophagy in melanocytes. | Kim, ES., et al. 2013. FEBS Lett. 587: 3955-60. PMID: 24188823
- Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway. | Wang, C., et al. 2015. Int J Biochem Cell Biol. 69: 173-82. PMID: 26494002
- miR-155 promotes cutaneous wound healing through enhanced keratinocytes migration by MMP-2. | Yang, L., et al. 2017. J Mol Histol. 48: 147-155. PMID: 28247149
- Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations. | Ara, A., et al. 2017. J Mol Graph Model. 75: 277-286. PMID: 28618335
- High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines. | Ghasemi, F., et al. 2018. Oncotarget. 9: 26064-26071. PMID: 29899842
- Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling. | Desjarlais, M. and Annabi, B. 2019. Chem Biol Drug Des. 93: 272-282. PMID: 30291676
- Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells. | Celentano, A., et al. 2021. J Oral Pathol Med. 50: 323-332. PMID: 31925966
- Harnessing the Noncanonical Keap1-Nrf2 Pathway for Human Cytomegalovirus Control. | Ghosh, AK., et al. 2023. J Virol. 97: e0016023. PMID: 36939350
Inhibitor of:
MMP-2, and MMP-9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARP 101, 5 mg | sc-203824 | 5 mg | $265.00 |