armadillo Antibody (H-7): sc-133181

Armadillo Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects armadillo protein of Drosophila melanogaster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-armadillo antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Armadillo protein plays a crucial role in cellular adhesion and signaling, functioning as a key component of adherens junctions, which are essential for maintaining tissue integrity and facilitating communication between cells. Armadillo (H-7) antibody recognizes a protein that interacts with adenomatous polyposis coli (APC) tumor suppressor, influencing processes such as cell differentiation and programmed cell death, which are vital for normal development and preventing tumorigenesis. Drosophila melanogaster serves as an invaluable model organism for studying these fundamental biological processes, given its well-characterized genome and conservation of many cellular mechanisms with higher eukaryotes. Anti-armadillo antibody (H-7) has become an essential tool for scientists investigating developmental biology and cancer research due to armadillo protein′s involvement in critical cellular pathways.

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armadillo Antibody (H-7) References:

1. The genome sequence of Drosophila melanogaster.  |  Adams, MD., et al. 2000. Science. 287: 2185-95. PMID: 10731132
2. Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo.  |  Townsley, FM. and Bienz, M. 2000. Curr Biol. 10: 1339-48. PMID: 11084333
3. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses.  |  Izawa, I., et al. 2002. J Biol Chem. 277: 5345-50. PMID: 11729199
4. Beyond cell adhesion: the role of armadillo proteins in the heart.  |  Swope, D., et al. 2013. Cell Signal. 25: 93-100. PMID: 23022961
5. The future of protein scaffolds as affinity reagents for purification.  |  Dias, AM. and Roque, AC. 2017. Biotechnol Bioeng. 114: 481-491. PMID: 27568828
6. Expression of sterile-α and armadillo motif containing protein (SARM) in rheumatoid arthritis monocytes correlates with TLR2-induced IL-1β and disease activity.  |  Thwaites, RS., et al. 2021. Rheumatology (Oxford). 60: 5843-5853. PMID: 33605409
7. Armadillo regulates nociceptive sensitivity in the absence of injury.  |  Hale, C., et al. 2022. Mol Pain. 18: 17448069221111155. PMID: 35712882
8. Autophagy protein ULK1 interacts with and regulates SARM1 during axonal injury.  |  Choi, HMC., et al. 2022. Proc Natl Acad Sci U S A. 119: e2203824119. PMID: 36375051
9. Structures of Vac8-containing protein complexes reveal the underlying mechanism by which Vac8 regulates multiple cellular processes.  |  Kim, H., et al. 2023. Proc Natl Acad Sci U S A. 120: e2211501120. PMID: 37094131
10. A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo.  |  Hayashi, S., et al. 1997. Proc Natl Acad Sci U S A. 94: 242-7. PMID: 8990193
11. Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.  |  Wang, YX., et al. 1998. J Cell Biol. 140: 1063-74. PMID: 9490720
12. Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.  |  Ahmed, Y., et al. 1998. Cell. 93: 1171-82. PMID: 9657150

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-armadillo Antibody (H-7) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

armadillo Antibody (H-7) Specifications

Alternate Product Name: armadillo

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: armadillo

Epitope Species: Drosophila melanogaster

Product Reactivity/Detection: armadillo

Species Reactivity/Detection: d

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for armadillo Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin