ARL6IP4 Antibody (ZZ-8): sc-81894
- ARL6IP4 Antibody (ZZ-8) is a mouse monoclonal IgG2a κ ARL6IP4 antibody provided at 100 µg/ml
- raised against recombinant ARL6IP4 of human origin
- recommended for detection of ARL6IP4 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ARL6IP4 Antibody (ZZ-8). This work is in progress.
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ARL6IP4 Antibody (ZZ-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects ARL6IP4 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ARL6IP4 (ZZ-8) antibody is available as a non-conjugated anti-ARL6IP4 antibody. ARL6IP4, also known as ADP-ribosylation-like factor 6 interacting protein 4, SR-25, or SRp25, is a hydrophilic nuclear protein consisting of 360 amino acids, predominantly expressed in the testis and thymus. ARL6IP4 plays a crucial role in RNA splicing, as indicated by its serine-arginine repeat (SR) domain, which is characteristic of many pre-mRNA splicing factors. ARL6IP4 contains at least fifteen putative phosphorylation sites, highlighting its potential for post-translational modifications that can regulate activity and interactions. ARL6IP4 functionally interacts with Rac 1, a GTP-binding protein of the Ras superfamily, suggesting involvement in the regulation of Rac 1-dependent signaling pathways, which are essential for various cellular processes, including cell migration and proliferation. At the amino acid level, human and mouse ARL6IP4 proteins exhibit 77.7% identity, underscoring the conservation of this protein′s function across species.
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ARL6IP4 Antibody (ZZ-8) References:
- Molecular cloning and expression analysis of a putative nuclear protein, SR-25. | Sasahara, K., et al. 2000. Biochem Biophys Res Commun. 269: 444-50. PMID: 10708573
- Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region. | Shink, E., et al. 2005. Am J Med Genet B Neuropsychiatr Genet. 135B: 50-8. PMID: 15768393
- Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants. | Ben-Ari, S., et al. 2006. J Neurochem. 97 Suppl 1: 24-34. PMID: 16635247
- Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. | Lehrmann, E., et al. 2006. PLoS One. 1: e114. PMID: 17205118
- Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis. | Lee, SC., et al. 2007. Proteomics. 7: 4112-22. PMID: 17952876
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARL6IP4 Antibody (ZZ-8) | sc-81894 | 100 µg/ml | $316.00 |