Molecular structure of ARL-17477 dihydrochloride, CAS Number: 866914-87-6
ARL-17477 dihydrochloride (CAS 866914-87-6)
Alternate Names:
N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride
Application:
ARL-17477 dihydrochloride is A NOS1 (nNOS) inhibitor
CAS Number:
866914-87-6
Molecular Weight:
442.83
Molecular Formula:
C20H20ClN3S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ARL-17477 dihydrochloride may be used in cell signaling studies. ARL-17477 is an NOS1 (nNOS) specific inhibitor. The IC50 against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.
ARL-17477 dihydrochloride (CAS 866914-87-6) References
- ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. | O'Neill, MJ., et al. 2000. Brain Res. 871: 234-44. PMID: 10899290
- Influence of the selective neuronal NO synthase inhibitor ARL 17477 on nitrergic neurotransmission in porcine stomach. | Lefebvre, RA., et al. 2005. Eur J Pharmacol. 525: 143-9. PMID: 16257402
- TRPA1, NMDA receptors and nitric oxide mediate mechanical hyperalgesia induced by local injection of magnesium sulfate into the rat hind paw. | Srebro, DP., et al. 2015. Physiol Behav. 139: 267-73. PMID: 25449407
- Neuronal Nitric Oxide Synthase is Involved in Vascular Hyporeactivity and Multiple Organ Dysfunction Associated with Hemorrhagic Shock. | Sordi, R., et al. 2016. Shock. 45: 525-33. PMID: 26863124
- Effect of nitrergic system on colonic motility in a rat model of irritable bowel syndrome. | Temiz, TK., et al. 2016. Indian J Pharmacol. 48: 424-429. PMID: 27756955
- Cued memory reconsolidation in rats requires nitric oxide. | Bal, NV., et al. 2017. Eur J Neurosci. 45: 643-647. PMID: 27987370
- Optogenetic Stimulation Reduces Neuronal Nitric Oxide Synthase Expression After Stroke. | Pendharkar, AV., et al. 2021. Transl Stroke Res. 12: 347-356. PMID: 32661768
- Differential Respiratory Response of Isolated Cardiac Mitochondria from Young and Aged Mice towards Nitric Oxide Synthase Inhibitors | Siva SVP. Sakamuri, Venkata NLR. Sure, Jared A. Sperling, Padmini S. Mahalingam, Monica H. Dholakia, Wesley R. Evans, Prasad VG. Katakam. 2018. FASEB. 32: 901.12-901.12.
- Assessing Mitochondrial Respiratory Function in Isolated Mouse Brain Microvessels using Seahorse XFe Analyzer: Role of Neuronal Nitric Oxide Synthase | Venkata NLR. Sure, Siva SVP. Sakamuri, Jared A. Sperling, Ivan Merdzo, Wesley R. Evans, Ibolya Rutkai, David W. Busija, Prasad VG. Katakam. 2018. FASEB. 32: 577.5-577.5.
Inhibitor of:
NOS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARL-17477 dihydrochloride, 5 mg | sc-391011 | 5 mg | $163.00 | |||
ARL-17477 dihydrochloride, 25 mg | sc-391011A | 25 mg | $714.00 |