Arkadia Antibody (1-KK14): sc-134270

Arkadia Antibody (1-KK14) is a mouse monoclonal IgG2a kappa light chain antibody that detects Arkadia protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Arkadia antibody (1-KK14) is available as the non-conjugated format. Arkadia (1-KK14) antibody recognizes a protein that plays a crucial role in early embryonic development, particularly in vertebrate body plan formation. Arkadia (1-KK14) monoclonal antibody targets a protein primarily located in the nucleus, where Arkadia acts as a key regulator of the nodal signaling pathway, essential for mesoderm and endoderm induction. By potentiating specific transforming growth factor-beta family members′ activity, Arkadia facilitates communication between embryonic and extraembryonic tissues, ensuring proper cell differentiation and organization during early development. The human Arkadia gene, located on chromosome 15q21, encodes a 441 amino acid protein, while its murine counterpart, found on chromosome 9 at 39.0 cM, encodes a larger 989 amino acid protein. Understanding Arkadia′s function and localization is vital, as disruptions in Arkadia′s activity can lead to developmental abnormalities and impact overall signaling mechanisms governing embryogenesis.

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Arkadia Antibody (1-KK14) References:

1. Nodal signalling in vertebrate development.  |  Schier, AF. and Shen, MM. 2000. Nature. 403: 385-9. PMID: 10667782
2. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.  |  Episkopou, V., et al. 2001. Nature. 410: 825-30. PMID: 11298452
3. Arkadia enhances nodal-related signalling to induce mesendoderm.  |  Niederländer, C., et al. 2001. Nature. 410: 830-4. PMID: 11298453
4. Vertebrate development: Et in Arkadia.  |  Patten, I. and Placzek, M. 2001. Curr Biol. 11: R616-9. PMID: 11516970
5. Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation.  |  Erker, Y., et al. 2013. Mol Cell Biol. 33: 2163-77. PMID: 23530056
6. Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control.  |  Sun, H., et al. 2014. Mol Cell Biol. 34: 2981-95. PMID: 24912682
7. Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6.  |  Tsubakihara, Y., et al. 2015. J Biochem. 158: 61-71. PMID: 25762727
8. The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.  |  Mizutani, A., et al. 2016. Oncogene. 35: 3514-23. PMID: 26522722
9. Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis.  |  Hou, F., et al. 2018. Int J Mol Med. 41: 1315-1322. PMID: 29286088
10. Arkadia-SKI/SnoN signaling differentially regulates TGF-β-induced iTreg and Th17 cell differentiation.  |  Xu, H., et al. 2021. J Exp Med. 218: PMID: 34473197
11. Unveiling the Essential Role of Arkadia's Non-RING Elements in the Ubiquitination Process.  |  Birkou, M., et al. 2022. Int J Mol Sci. 23: PMID: 36142504
12. E2 Partner Tunes the Ubiquitylation Specificity of Arkadia E3 Ubiquitin Ligase.  |  Delegkou, GN., et al. 2023. Cancers (Basel). 15: PMID: 36831384

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Arkadia Antibody (1-KK14) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Arkadia Antibody (1-KK14) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Arkadia Antibody (1-KK14) Specifications

Alternate Product Name: Arkadia

Product Clone Name: 1-KK14

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-109

Epitope Target: Arkadia

Epitope Species: human

Product Reactivity/Detection: Arkadia

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Arkadia Antibody (1-KK14): N/A