Molecular structure of Aristolactam I, CAS Number: 13395-02-3
Aristolactam I (CAS 13395-02-3)
Alternate Names:
8-Methoxybenzo[f]-1,3-benzodioxolo[6,5,4-cd]indol-5(6H)-one
CAS Number:
13395-02-3
Molecular Weight:
293.27
Molecular Formula:
C17H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aristolactam I is a chemical compound that functions as an inhibitor of DNA topoisomerase II. It exerts its mechanism of action by binding to the enzyme and preventing the resealing of DNA strands that have been cleaved by the enzyme during its normal cellular processes. This interference with the enzyme′s activity leads to the accumulation of DNA strand breaks and ultimately inhibits cell proliferation. Aristolactam I may target the catalytic activity of DNA topoisomerase II, disrupting its essential role in DNA replication and transcription. Aristolactam I′s mechanism of action involves the inhibition of an important cellular process, making it useful for studying the role of DNA topoisomerases in cellular function.
Aristolactam I (CAS 13395-02-3) References
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- Effect of base sequence context on the conformational heterogeneity of aristolactam-I adducted DNA: structural and energetic insights into sequence-dependent repair and mutagenicity. | Kathuria, P., et al. 2016. Toxicol Res (Camb). 5: 197-209. PMID: 30090337
- Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography-Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure. | Chan, CK., et al. 2021. Chem Res Toxicol. 34: 144-153. PMID: 33410325
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- Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury. | Wang, Y., et al. 2021. Biochem Pharmacol. 193: 114807. PMID: 34673015
- Study of the Contents of Analogues of Aristolochic Acid in Houttuynia cordata by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry. | Yu, X., et al. 2022. Foods. 11: PMID: 35159454
- Oral subacute nephrotoxicity of aristololactam I in rats. | Wang, C., et al. 2022. Toxicology. 475: 153228. PMID: 35690179
- Studies on the metabolism of aristolochic acids I and II. | Krumbiegel, G., et al. 1987. Xenobiotica. 17: 981-91. PMID: 3673113
- Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy. | Au, CK., et al. 2023. Chem Res Toxicol. 36: 322-329. PMID: 36757010
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aristolactam I, 5 mg | sc-480598 | 5 mg | $430.00 |