Molecular structure of Aristoforin, CAS Number: 849215-53-8
Aristoforin (CAS 849215-53-8)
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Alternate Names:
SIRT inhibitor
Application:
Aristoforin is a highly-stable SIRT inhibitor used for research purposes
CAS Number:
849215-53-8
Purity:
≥95%
Molecular Weight:
594.83
Molecular Formula:
C37H54O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aristoforin is a stable and water-soluble derivative of hyperforin inducing apoptosis. Antitumor agent. Aristoforin also inhibits sirtuins.
Aristoforin (CAS 849215-53-8) References
- Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent. | Gartner, M., et al. 2005. Chembiochem. 6: 171-7. PMID: 15593112
- Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. | Gey, C., et al. 2007. Angew Chem Int Ed Engl. 46: 5219-22. PMID: 17516596
- Indoloquinolizidine derivatives as novel and potent apoptosis inducers and cell-cycle blockers. | Wehner, F., et al. 2008. Chembiochem. 9: 401-5. PMID: 18189263
- Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent. | Lorusso, G., et al. 2009. Eur J Cancer. 45: 1474-84. PMID: 19223175
- Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins). | Lawson, M., et al. 2010. Biochim Biophys Acta. 1799: 726-39. PMID: 20601279
- Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. | Liu, JY., et al. 2011. Chem Biol Interact. 190: 91-101. PMID: 21376709
- In-vitro antitumor activity evaluation of hyperforin derivatives. | Sun, F., et al. 2011. J Asian Nat Prod Res. 13: 688-99. PMID: 21751836
- DNA-protective activities of hyperforin and aristoforin. | Ševčovičová, A., et al. 2015. Toxicol In Vitro. 29: 631-7. PMID: 25678043
- Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. | Šemeláková, M., et al. 2016. Biomed Pharmacother. 81: 38-47. PMID: 27261575
- Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity. | Cottet, K., et al. 2016. J Med Chem. 59: 9560-9566. PMID: 27669815
Inhibitor of:
SIRT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aristoforin, 1 mg | sc-202958 | 1 mg | $154.00 |