Molecular structure of Aripiprazole-d8 (Butyl-d8), CAS Number: 1089115-04-7
Aripiprazole-d8 (Butyl-d8) (CAS 1089115-04-7)
Alternate Names:
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy-d8]-3,4-dihydro-2(1H)-quinolinone
CAS Number:
1089115-04-7
Molecular Weight:
456.43
Molecular Formula:
C23H19D8Cl2N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Aripiprazole-d8 (Butyl-d8), a deuterium-labeled version of aripiprazole with deuterium atoms replacing hydrogen atoms at the butyl chain, is a compound of interest in the field of analytical chemistry. As a stable isotope-labeled internal standard, it is specifically designed for use in mass spectrometry-based assays to accurately measure the parent compound, aripiprazole, in biological samples. The incorporation of deuterium increases the mass of the butyl chain, allowing Aripiprazole-d8 (Butyl-d8) to be distinguished from the non-deuterated compound, thereby improving the precision of chemical kinetic studies. Research utilizing Aripiprazole-d8 (Butyl-d8) focuses on understanding the absorption, distribution, metabolism, and excretion (ADME) of aripiprazole.
Aripiprazole-d8 (Butyl-d8) (CAS 1089115-04-7) References
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- SPE-UPLC-MS/MS method for sensitive and rapid determination of aripiprazole in human plasma to support a bioequivalence study. | Patel, DP., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 925: 20-5. PMID: 23510852
- Transfer of aripiprazole to breast milk: a case report. | Nordeng, H., et al. 2014. J Clin Psychopharmacol. 34: 272-5. PMID: 24525642
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- Comparison of conventional liquid chromatography-tandem mass spectrometry versus microflow liquid chromatography-tandem mass spectrometry within the framework of full method validation for simultaneous quantification of 40 antidepressants and neuroleptics in whole blood. | Steuer, AE., et al. 2015. J Chromatogr A. 1381: 87-100. PMID: 25596763
- Efficient synthesis of deuterium labeled hydroxyzine and aripiprazole. | Vohra, M., et al. 2015. J Labelled Comp Radiopharm. 58: 304-7. PMID: 26011470
- Population pharmacokinetics of aripiprazole in healthy Korean subjects. | Jeon, JY., et al. 2016. Int J Clin Pharmacol Ther. 54: 293-304. PMID: 26902506
- Development and validation of HILIC-ESI/MS/MS methods for simultaneous quantitation of several antipsychotics in human plasma and blood. | De Meulder, M., et al. 2016. Bioanalysis. 8: 765-94. PMID: 27005848
- Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies. | Wojnicz, A., et al. 2018. J Pharm Biomed Anal. 151: 116-125. PMID: 29324280
- Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial. | Veselinović, T., et al. 2019. J Clin Psychopharmacol. 39: 550-560. PMID: 31688449
- Concentrations of aripiprazole and dehydroaripiprazole in hair segments from deceased individuals with mental disorders. | Rygaard, K., et al. 2020. Forensic Sci Int. 317: 110523. PMID: 33010563
- Bioequivalence of 2 Aripiprazole Orally Disintegrating Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions. | Xiang, J., et al. 2021. Clin Pharmacol Drug Dev. 10: 840-849. PMID: 34105265
- Simultaneous quantification of 19 analytes in breast milk by liquid chromatography-tandem mass spectrometry (LC-MS/MS). | Monfort, A., et al. 2021. J Pharm Biomed Anal. 204: 114236. PMID: 34273657
- Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches. | Wang, Y., et al. 2021. Pharmaceutics. 13: PMID: 34452197
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aripiprazole-d8 (Butyl-d8), 1 mg | sc-207302 | 1 mg | $337.00 |