Molecular structure of Aripiprazole-d8, CAS Number: 1089115-06-9
Aripiprazole-d8 (CAS 1089115-06-9)
Alternate Names:
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydrocarbostyril; 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydro-2(1H)-quinolinone
Application:
Aripiprazole-d8 is a selective dopamine D2-receptor antagonist
CAS Number:
1089115-06-9
Molecular Weight:
456.43
Molecular Formula:
C23H19D8Cl2N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aripiprazole-d8 is a deuterated version of aripiprazole, which is a selective D2DR (dopamine D2-receptor) antagonist with dopamine autoreceptor agonist activity. The incorporation of deuterium atoms makes aripiprazole-d8 an invaluable tool in the realm of analytical chemistry, especially for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. In MS studies, the increased mass allows for the distinction between the deuterated compound and its non-deuterated counterpart, facilitating the study of metabolism and distribution within biological systems. Users have reported separation of this compound and aripiprazole under reverse-phase H and normal-phase.
Aripiprazole-d8 (CAS 1089115-06-9) References
- A liquid chromatography-electrospray ionization-tandem mass spectrometry method for quantitation of aripiprazole in human plasma. | Lin, SN., et al. 2009. J Anal Toxicol. 33: 237-42. PMID: 19671242
- SPE-UPLC-MS/MS method for sensitive and rapid determination of aripiprazole in human plasma to support a bioequivalence study. | Patel, DP., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 925: 20-5. PMID: 23510852
- Quantitative levels of aripiprazole parent drug and metabolites in urine. | McEvoy, J., et al. 2014. Psychopharmacology (Berl). 231: 4421-8. PMID: 25345737
- Comparison of conventional liquid chromatography-tandem mass spectrometry versus microflow liquid chromatography-tandem mass spectrometry within the framework of full method validation for simultaneous quantification of 40 antidepressants and neuroleptics in whole blood. | Steuer, AE., et al. 2015. J Chromatogr A. 1381: 87-100. PMID: 25596763
- Efficient synthesis of deuterium labeled hydroxyzine and aripiprazole. | Vohra, M., et al. 2015. J Labelled Comp Radiopharm. 58: 304-7. PMID: 26011470
- Development and validation of HILIC-ESI/MS/MS methods for simultaneous quantitation of several antipsychotics in human plasma and blood. | De Meulder, M., et al. 2016. Bioanalysis. 8: 765-94. PMID: 27005848
- Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies. | Wojnicz, A., et al. 2018. J Pharm Biomed Anal. 151: 116-125. PMID: 29324280
- Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial. | Veselinović, T., et al. 2019. J Clin Psychopharmacol. 39: 550-560. PMID: 31688449
- Concentrations of aripiprazole and dehydroaripiprazole in hair segments from deceased individuals with mental disorders. | Rygaard, K., et al. 2020. Forensic Sci Int. 317: 110523. PMID: 33010563
- Simultaneous quantification of 19 analytes in breast milk by liquid chromatography-tandem mass spectrometry (LC-MS/MS). | Monfort, A., et al. 2021. J Pharm Biomed Anal. 204: 114236. PMID: 34273657
- Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches. | Wang, Y., et al. 2021. Pharmaceutics. 13: PMID: 34452197
- Novel antipsychotic agents with dopamine autoreceptor agonist properties: synthesis and pharmacology of 7-[4-(4-phenyl-1-piperazinyl)butoxy]-3,4-dihydro-2(1H)-quinolinone derivatives. | Oshiro, Y., et al. 1998. J Med Chem. 41: 658-67. PMID: 9513593
- Spontaneous brain magnetic activity in schizophrenia patients treated with aripiprazole. | Cañive, JM., et al. 1998. Psychopharmacol Bull. 34: 101-5. PMID: 9580382
Inhibitor of:
D2DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aripiprazole-d8, 1 mg | sc-207301 | 1 mg | $330.00 |