ARHGAP6 Antibody (D-5): sc-81938

ARHGAP6 Antibody (D-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects ARHGAP6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ARHGAP6 antibody (D-5) is available as a non-conjugated format. ARHGAP6, also known as Rho GTPase activating protein 6 or RHOGAPX-1, plays a crucial role in cellular signaling by acting as a GTPase-activating protein specific for RhoA, which is essential for regulating actin cytoskeleton and promoting actin remodeling. ARHGAP6 is predominantly located in cytoplasm, where ARHGAP6 colocalizes with actin filaments, facilitating recruitment of F-actin through its N-terminus. Three SH3 binding domains and a Rho GAP domain in ARHGAP6′s structure underscore functional versatility and importance in various cellular processes, including cell migration and adhesion. ARHGAP6 gene is situated on X chromosome in a region associated with microphthalmia with linear skin defects (MLS), a rare X-linked dominant male-lethal syndrome characterized by severe developmental anomalies. Although ARHGAP6 is absent in MLS patients, ARHGAP6 does not appear to directly contribute to disease pathogenesis, highlighting complexity of genetic interactions in developmental disorders.

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ARHGAP6 Antibody (D-5) References:

1. Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA.  |  Prakash, SK., et al. 2000. Hum Mol Genet. 9: 477-88. PMID: 10699171
2. Expression in Escherichia coli of human ARHGAP6 gene and purification of His-tagged recombinant protein.  |  Ochocka, AM., et al. 2003. Acta Biochim Pol. 50: 239-47. PMID: 12673365
3. Microphthalmia with linear skin defects syndrome (MLS): a male with a mosaic paracentric inversion of Xp.  |  Kutsche, K., et al. 2002. Cytogenet Genome Res. 99: 297-302. PMID: 12900578
4. Imaging RNA polymerase-amelogenin gene complexes with single molecule resolution using atomic force microscopy.  |  Crampton, N., et al. 2006. Eur J Oral Sci. 114 Suppl 1: 133-8; discussion 164-5, 380-1. PMID: 16674675
5. An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.  |  Tribioli, C., et al. 1996. Proc Natl Acad Sci U S A. 93: 695-9. PMID: 8570618
6. Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects.  |  Schaefer, L., et al. 1997. Genomics. 46: 268-77. PMID: 9417914
7. Ectopic expression of RET results in microphthalmia and tumors in the retinal pigment epithelium.  |  Schmidt, A., et al. 1999. Int J Cancer. 80: 600-5. PMID: 9935163

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARHGAP6 Antibody (D-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ARHGAP6 Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARHGAP6 Antibody (D-5) Specifications

Alternate Product Name: ARHGAP6

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 531-637

Epitope Target: ARHGAP6

Epitope Species: human

Product Reactivity/Detection: ARHGAP6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ARHGAP6 Antibody (D-5): N/A