ARHGAP19 Antibody (B-5): sc-514960

ARHGAP19 Antibody (B-5) is a mouse monoclonal IgG1 antibody that detects ARHGAP19 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARHGAP19, or Rho GTPase activating protein 19, is a 494 amino acid protein that plays a crucial role in regulating Rho-type GTPases by accelerating the hydrolysis of GTP, thereby promoting the conversion of these GTPases to their inactive GDP-bound state. This function is vital for controlling various cellular processes, including cell proliferation, migration, and differentiation, as well as actin remodeling, which is essential for maintaining cell shape and motility. ARHGAP19 is predominantly localized in the nucleus and is strongly expressed in fetal liver, lung, brain, heart, kidney, and pancreas, while being present at lower levels in adult ovary, spleen, and thymus. The presence of multiple alternatively spliced isoforms of ARHGAP19, encoded by a gene located on human chromosome 10, adds complexity to its regulatory functions and interactions within the cell. Anti-ARHGAP19 antibody (B-5) is an invaluable tool for researchers studying the intricate roles of Rho GTPases in cellular dynamics and signaling pathways.

The preferred ARHGAP19 antibody is ARHGAP19 Antibody (B-11): sc-398428.