ARHGAP17 Antibody (G-6): sc-514438
- ARHGAP17 Antibody (G-6) is a mouse monoclonal IgG1 κ ARHGAP17 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 303-327 within an internal region of ARHGAP17 of human origin
- ARHGAP17 Antibody (G-6) is recommended for detection of ARHGAP17 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ARHGAP17 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ARHGAP17 Antibody (G-6) for WB applications. This reagent is now offered in a bundle with ARHGAP17 Antibody (G-6) (see ordering information below).
ARHGAP17 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARHGAP17 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ARHGAP17 antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARHGAP17, also known as Rho GTPase activating protein 17, plays a crucial role in cellular signaling by regulating the activity of Rho family GTPases, particularly Cdc42, which is essential for maintaining tight junctions and apical polarity in epithelial cells. This regulation is vital for proper cell adhesion and barrier function, impacting processes such as tissue integrity and cellular communication. ARHGAP17 is predominantly expressed in the heart and placenta, highlighting its importance in these tissues. ARHGAP17 contains a BAR domain and a Rho-GAP domain, which facilitate its function as a GTPase activator, converting Cdc42 to its inactive GDP-bound state. ARHGAP17 may influence calcium-dependent exocytosis by modulating the GTPase activity of Rho family proteins and reorganizing cortical actin filaments. ARHGAP17 exists as seven alternative splice variants, which may contribute to its diverse functional roles in different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARHGAP17 Antibody (G-6) References:
- Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. | Harada, A., et al. 2000. J Biol Chem. 275: 36885-91. PMID: 10967100
- Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. | Reczek, D. and Bretscher, A. 2001. J Cell Biol. 153: 191-206. PMID: 11285285
- Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. | Richnau, N. and Aspenström, P. 2001. J Biol Chem. 276: 35060-70. PMID: 11431473
- Identification and functional characterization of nadrin variants, a novel family of GTPase activating protein for rho GTPases. | Furuta, B., et al. 2002. J Neurochem. 82: 1018-28. PMID: 12358749
- BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. | Peter, BJ., et al. 2004. Science. 303: 495-9. PMID: 14645856
- Characterization of human ARHGAP10 gene in silico. | Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 1201-6. PMID: 15375573
- Identification and characterization of ARHGAP27 gene in silico. | Katoh, Y. and Katoh, M. 2004. Int J Mol Med. 14: 943-7. PMID: 15492870
- Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. | Dubois, T., et al. 2005. Nat Cell Biol. 7: 353-64. PMID: 15793564
- A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. | Wells, CD., et al. 2006. Cell. 125: 535-48. PMID: 16678097
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARHGAP17 Antibody (G-6) | sc-514438 | 200 µg/ml | $316.00 | |||
ARHGAP17 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-526370 | 200 µg Ab; 10 µg BP | $354.00 | |||
ARHGAP17 Antibody (G-6) AC | sc-514438 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ARHGAP17 Antibody (G-6) HRP | sc-514438 HRP | 200 µg/ml | $316.00 | |||
ARHGAP17 Antibody (G-6) FITC | sc-514438 FITC | 200 µg/ml | $330.00 | |||
ARHGAP17 Antibody (G-6) PE | sc-514438 PE | 200 µg/ml | $343.00 | |||
ARHGAP17 Antibody (G-6) Alexa Fluor® 488 | sc-514438 AF488 | 200 µg/ml | $357.00 | |||
ARHGAP17 Antibody (G-6) Alexa Fluor® 546 | sc-514438 AF546 | 200 µg/ml | $357.00 | |||
ARHGAP17 Antibody (G-6) Alexa Fluor® 594 | sc-514438 AF594 | 200 µg/ml | $357.00 | |||
ARHGAP17 Antibody (G-6) Alexa Fluor® 647 | sc-514438 AF647 | 200 µg/ml | $357.00 | |||
ARHGAP17 Antibody (G-6) Alexa Fluor® 680 | sc-514438 AF680 | 200 µg/ml | $357.00 | |||
ARHGAP17 Antibody (G-6) Alexa Fluor® 790 | sc-514438 AF790 | 200 µg/ml | $357.00 | |||
ARHGAP17 (G-6) Neutralizing Peptide | sc-514438 P | 100 µg/0.5 ml | $68.00 |