Date published: 2025-12-5

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(Arg)9 (CAS 143413-47-2)

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Alternate Names:
Nona-arginine
Application:
(Arg)9 is a cell-penetrating peptide made up of 9 arginine residues
CAS Number:
143413-47-2
Molecular Weight:
1423.69
Molecular Formula:
C54H110N36O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(Arg)9, a polyarginine peptide, is primarily used in biochemical and cellular research due to its ability to facilitate cellular uptake of various molecules. This attribute makes it an important tool for investigating intracellular processes and enhancing the delivery of biomolecules such as nucleic acids and proteins into cells. In studies focused on gene delivery, (Arg)9 is explored for its potential to act as a non-viral vector, simplifying the transfection process without the complexities associated with viral systems. Additionally, this peptide is utilized in the study of protein-protein interactions within the cellular environment, helping to map out interaction networks that are critical for understanding cellular functions. Researchers also employ (Arg)9 in the development of sensor technologies, where it aids in the creation of sensitive and selective detection systems for biomarkers and other biologically relevant molecules.


(Arg)9 (CAS 143413-47-2) References

  1. Nona-arginine facilitates delivery of quantum dots into cells via multiple pathways.  |  Xu, Y., et al. 2010. J Biomed Biotechnol. 2010: 948543. PMID: 21048930
  2. Thermodynamics of lipid interactions with cell-penetrating peptides.  |  Sauder, R., et al. 2011. Methods Mol Biol. 683: 129-55. PMID: 21053127
  3. Distinct transduction modes of arginine-rich cell-penetrating peptides for cargo delivery into tumor cells.  |  Ma, DX., et al. 2011. Int J Pharm. 419: 200-8. PMID: 21843610
  4. Endocytic Trafficking of Nanoparticles Delivered by Cell-penetrating Peptides Comprised of Nona-arginine and a Penetration Accelerating Sequence.  |  Liu, BR., et al. 2013. PLoS One. 8: e67100. PMID: 23840594
  5. Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed siRNA.  |  Zeller, S., et al. 2015. Chem Biol. 22: 50-62. PMID: 25544044
  6. An easy-to-detect nona-arginine peptide for epidermal targeting.  |  Clède, S., et al. 2015. Chem Commun (Camb). 51: 2687-9. PMID: 25574834
  7. Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium.  |  Melikov, K., et al. 2015. Biochem J. 471: 221-30. PMID: 26272944
  8. Bioreducible branched poly(modified nona-arginine) cell-penetrating peptide as a novel gene delivery platform.  |  Yoo, J., et al. 2017. J Control Release. 246: 142-154. PMID: 27170226
  9. Arginine-Rich Cell-Penetrating Peptides Require Nucleolin and Cholesterol-Poor Subdomains for Translocation across Membranes.  |  Lorents, A., et al. 2018. Bioconjug Chem. 29: 1168-1177. PMID: 29510042
  10. Cell-Selective Delivery of MicroRNA with a MicroRNA-Peptide Conjugate Nanocomplex.  |  Xiao, X., et al. 2018. Chem Asian J. 13: 3845-3849. PMID: 30354014
  11. Cholesterol re-organisation and lipid de-packing by arginine-rich cell penetrating peptides: Role in membrane translocation.  |  Almeida, C., et al. 2019. PLoS One. 14: e0210985. PMID: 30673771
  12. Protein labeling approach to improve lysosomal targeting and efficacy of antibody-drug conjugates.  |  Han, Y., et al. 2020. Org Biomol Chem. 18: 3229-3233. PMID: 32108212
  13. Surface charge density and fatty acids enhance the membrane permeation rate of CPP-cargo complexes.  |  Via, MA., et al. 2020. Soft Matter. 16: 9890-9898. PMID: 33020785
  14. Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity in Vitro and after Sublingual Immunization.  |  Kelly, SH., et al. 2021. ACS Biomater Sci Eng. 7: 1876-1888. PMID: 33775089
  15. Free Energy Analyses of Cell-Penetrating Peptides Using the Weighted Ensemble Method.  |  Choe, S. 2021. Membranes (Basel). 11: PMID: 34940475

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(Arg)9, 1 mg

sc-396814
1 mg
$94.00

(Arg)9, 10 mg

sc-396814A
10 mg
$918.00

(Arg)9, 50 mg

sc-396814B
50 mg
$3264.00

(Arg)9, 100 mg

sc-396814C
100 mg
$5100.00

(Arg)9, 500 mg

sc-396814D
500 mg
$12750.00