ARFGAP2 Antibody (RG-7): sc-100979
- ARFGAP2 Antibody (RG-7) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant ARFGAP2 of human origin
- recommended for detection of ARFGAP2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ARFGAP2 Antibody (RG-7). This work is in progress.
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ARFGAP2 Antibody (RG-7) is a mouse monoclonal IgG2a antibody that detects ARFGAP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ARFGAP2, also known as ZNF289, plays a crucial role as a GTPase-activating protein for the ADP-ribosylation factor (ARF) family, which is essential for regulating vesicle trafficking and signal transduction in eukaryotic cells. ARFGAP2 is primarily localized to the cytoplasmic side of the Golgi apparatus, where ARFGAP2 is involved in the assembly of coat proteins and the maintenance of organelle integrity. The presence of one ARF-GAP domain in ARFGAP2 allows effective modulation of ARF proteins, thereby influencing the coordination of spectrin interactions with Golgi membranes and the association of actin to the Golgi through Rho family-dependent G-protein localization. Additionally, ARFGAP2 is associated with COP-I-coated vesicles, highlighting ARFGAP2′s importance in intracellular transport processes. ARFGAP2′s ability to regulate these pathways underscores ARFGAP2′s significance in maintaining cellular homeostasis and facilitating proper cellular communication, making ARFGAP2 a valuable target for research in cell biology and related fields.
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ARFGAP2 Antibody (RG-7) References:
- Two human ARFGAPs associated with COP-I-coated vesicles. | Frigerio, G., et al. 2007. Traffic. 8: 1644-55. PMID: 17760859
- Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. | Weimer, C., et al. 2008. J Cell Biol. 183: 725-35. PMID: 19015319
- Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat. | Kliouchnikov, L., et al. 2009. Mol Biol Cell. 20: 859-69. PMID: 19109418
- The GAP domain and the SNARE, coatomer and cargo interaction region of the ArfGAP2/3 Glo3 are sufficient for Glo3 function. | Schindler, C., et al. 2009. Traffic. 10: 1362-75. PMID: 19602196
- ARFGAP2 and ARFGAP3 are essential for COPI coat assembly on the Golgi membrane of living cells. | Kartberg, F., et al. 2010. J Biol Chem. 285: 36709-20. PMID: 20858901
- Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion. | Bauer, MC., et al. 2011. Mol Biosyst. 7: 2196-204. PMID: 21528130
- Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity. | Pevzner, I., et al. 2012. Traffic. 13: 849-56. PMID: 22375848
- The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes. | Estrada, AF., et al. 2015. Biol Open. 4: 792-802. PMID: 25964658
- ArfGAP3 regulates vesicle transport and glucose uptake in myoblasts. | Li, S., et al. 2023. Cell Signal. 103: 110551. PMID: 36476390
- ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation. | Poddar, S., et al. 2025. Cell.. PMID: 39947179
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARFGAP2 Antibody (RG-7) | sc-100979 | 100 µg/ml | $339.00 |