ARFGAP1/3 Antibody (G-11): sc-374328

ARFGAP1/3 Antibody (G-11) is a mouse monoclonal IgG2a antibody that detects ARFGAP1/3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARFGAP1/3 plays a crucial role in the regulation of vesicular trafficking by acting as a GTPase-activating protein for members of the ADP ribosylation factor (ARF) family, which are essential for the transport of proteins and lipids within cells. ARFGAP1/3 is primarily localized in the perinuclear region, where ARFGAP1/3 facilitates the dissociation of coat proteins from Golgi-derived membranes and vesicles, thereby promoting efficient protein secretion and vesicle transport. ARFGAP1/3 activity is sensitive to phospholipids, highlighting ARFGAP1/3′s importance in cellular signaling and membrane dynamics. ARFGAP1/3 is predominantly expressed in endocrine glands and the testis, but ARFGAP1/3 is also significantly present in the adult brain, thymus, and lung, indicating diverse functional roles across different tissues. ARFGAP1/3 (G-11) antibody is an invaluable tool for researchers studying the intricate mechanisms of vesicular transport and the broader implications of ARF signaling in various physiological and pathological contexts.

The preferred ARFGAP1/3 antibody is ARFGAP1/3 Antibody (D-8): sc-365418.