Molecular structure of Arecaidine but-2-ynyl ester tosylate, CAS Number: 119630-77-2
Arecaidine but-2-ynyl ester tosylate (CAS 119630-77-2)
Alternate Names:
N-Methyl-1,2,5,6-tetrahydropyridine -3-carboxylic acid but-2-ynyl ester tosylate
Application:
Arecaidine but-2-ynyl ester tosylate is a potent, selective mAChR M2 activator
CAS Number:
119630-77-2
Molecular Weight:
365.44
Molecular Formula:
C11H15NO2•C7H8SO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist that shows 4.6-fold that is selectivity for mAChR M2 in the atrium versus those in the ileum.
Arecaidine but-2-ynyl ester tosylate (CAS 119630-77-2) References
- Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation. | Liu, J., et al. 2002. J Pharmacol Exp Ther. 302: 397-405. PMID: 12065743
- Electrophysiological characterization of cardiac muscarinic acetylcholine receptors: different subtypes mediate different potassium currents. | Shi, H., et al. 2003. Cell Physiol Biochem. 13: 59-74. PMID: 12649591
- Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill. | González, A., et al. 2004. BMC Neurosci. 5: 23. PMID: 15251036
- Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism. | Malomouzh, AI., et al. 2007. J Neurochem. 102: 2110-2117. PMID: 17561934
- Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3- and M2-dependent components of a motor/sensory system. | Finney, SM., et al. 2007. BJU Int. 100: 668-78. PMID: 17627783
- A spinal muscarinic M2 receptor-GABAergic disinhibition pathway that modulates peripheral inflammation in mice. | Yoon, SY., et al. 2007. Neuropharmacology. 53: 677-86. PMID: 17765931
- Maturation of stretch-induced contractile activity and its muscarinic regulation in isolated whole bladder strips from rat. | Gevaert, T., et al. 2010. Neurourol Urodyn. 29: 789-96. PMID: 18288706
- M(1)-like muscarinic acetylcholine receptors regulate fast-spiking interneuron excitability in rat dentate gyrus. | Chiang, PH., et al. 2010. Neuroscience. 169: 39-51. PMID: 20433901
- Role of Muscarinic Acetylcholine Receptor-2 in the Cerebellar Cortex in Cardiovascular Modulation in Anaesthetized Rats. | Zhang, C., et al. 2016. Neurochem Res. 41: 804-12. PMID: 26526144
- Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes. | Moser, U., et al. 1989. Br J Pharmacol. 96: 319-24. PMID: 2924082
- Neural Subtype-dependent Cholinergic Modulation of Neural Activities by Activation of Muscarinic 2 Receptors and G Protein-activated Inwardly Rectifying Potassium Channel in Rat Periaqueductal Gray Neurons. | Sugawara, S., et al. 2022. Neuroscience. 506: 1-13. PMID: 36270414
- The relative potencies of some agonists at M2 muscarinic receptors in guinea-pig ileum, atria and bronchi. | Barlow, RB. and Weston-Smith, P. 1985. Br J Pharmacol. 85: 437-40. PMID: 3896364
- Mechanism of prejunctional muscarinic receptor-mediated inhibition of neurogenic vasodilation in cerebral arteries. | Liu, J. and Lee, TJ. 1999. Am J Physiol. 276: H194-204. PMID: 9887033
Activator of:
mAChR M2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arecaidine but-2-ynyl ester tosylate, 10 mg | sc-203519 | 10 mg | $285.00 | |||
| US: Only available in the US | ||||||
Arecaidine but-2-ynyl ester tosylate, 50 mg | sc-203519A | 50 mg | $364.00 | |||
| US: Only available in the US | ||||||