Molecular structure of (−)-Arctiin, CAS Number: 20362-31-6
(−)-Arctiin (CAS 20362-31-6)
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Application:
(−)-Arctiin is a lignan derivative that downregulates Bcl-XL and inhibits HIV-1 integrase
CAS Number:
20362-31-6
Purity:
≥98%
Molecular Weight:
534.60
Molecular Formula:
C27H34O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(−)-Arctiin is used in biochemical research, particularly in the study of lignan compounds and their biological activities. This compound is a focus of investigations into its role in influencing signal transduction pathways and gene expression related to oxidative stress and inflammation. Researchers employ (−)-Arctiin to study its potential effects on cellular antioxidant systems, examining how it interacts with various molecular targets within cells. Additionally, (−)-Arctiin is used in the exploration of its effects on enzyme activity, particularly those involved in metabolic and detoxification processes.
(−)-Arctiin (CAS 20362-31-6) References
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- Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. | Iwakami, S., et al. 1992. Chem Pharm Bull (Tokyo). 40: 1196-8. PMID: 1394633
- Application of preparative high-speed counter-current chromatography for separation and purification of arctiin from Fructus Arctii. | Wang, X., et al. 2005. J Chromatogr A. 1063: 247-51. PMID: 15700478
- Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS. | Liu, S., et al. 2005. Phytochem Anal. 16: 86-9. PMID: 15881114
- The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme. | Kang, K., et al. 2007. Biol Pharm Bull. 30: 2352-9. PMID: 18057725
- Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L. | Gao, Q., et al. 2018. Acta Pharmacol Sin. 39: 787-801. PMID: 29698388
- Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway. | Zhou, Y., et al. 2020. Biomed Res Int. 2020: 2508952. PMID: 33123566
- The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway. | Liu, X., et al. 2021. Oxid Med Cell Longev. 2021: 5598980. PMID: 34336106
- Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling. | Zhou, B., et al. 2021. BMC Complement Med Ther. 21: 289. PMID: 34836523
- Arctiin Inhibits Cervical Cancer Cell Migration and Invasion through Suppression of S100A4 Expression via PI3K/Akt Pathway. | Lee, CY., et al. 2022. Pharmaceutics. 14: PMID: 35214097
- Arctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1. | Liu, Z. and Wu, Y. 2022. Bioengineered. 13: 10866-10874. PMID: 35473505
- Cytotoxic components of bardanae fructus (goboshi). | Moritani, S., et al. 1996. Biol Pharm Bull. 19: 1515-7. PMID: 8951177
- Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. | Vlietinck, AJ., et al. 1998. Planta Med. 64: 97-109. PMID: 9525100
Inhibitor of:
HIV-1 Integrase, and Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Arctiin, 25 mg | sc-202064 | 25 mg | $63.00 |