Arctigenin (CAS 7770-78-7)
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Arctigenin is a dibenzyl butyrolactone lignan agent with antiinflammatory and antioxidant properties. Studies describe arctigenin to potently block TNF- alpha production and NO secretion. MAP kinase studies show that arctigenin effectively inhibits the activity of MAP kinases and AP-1 activation through vigorous inhibition of MKK. Additional studies report that arctigenin acts as a potent inhibitor of PAC-1 activity. Arctigenin has also been shown to bind to kainic acid receptors and protect neurons from neurodegeneration induced by glutamate and inhibit HIV-1 integrase. Furthermore, this compound acts as an inhibitor of IkappaB phosphorylation. Arctigenin is an inhibitor of MEK-1 and Topo II. It exert its effects through multiple pathways, including the inhibition of tumor-promoting enzymes, the induction of apoptosis, and the interference with the cell cycle. Furthermore, arctigenin has demonstrated the ability to regulate the expression of several genes involved in cell cycle regulation, apoptosis, and inflammation.
Arctigenin (CAS 7770-78-7) References
- Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation. | Cho, JY., et al. 1999. J Pharm Pharmacol. 51: 1267-73. PMID: 10632084
- Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. | Jang, YP., et al. 2002. J Neurosci Res. 68: 233-40. PMID: 11948668
- Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. | Cho, MK., et al. 2004. Int Immunopharmacol. 4: 1419-29. PMID: 15313439
- Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. | Awale, S., et al. 2006. Cancer Res. 66: 1751-7. PMID: 16452235
- Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα. | Sun, Y., et al. 2018. Front Pharmacol. 9: 268. PMID: 29636686
- Arctigenin induces apoptosis in human hepatoblastoma cells. | Naoe, A., et al. 2019. Pediatr Surg Int. 35: 723-728. PMID: 30891641
- Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes. | Zhong, Y., et al. 2019. Nat Commun. 10: 4523. PMID: 31586053
- Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer. | Qiao, S., et al. 2020. Cancer Lett. 491: 162-179. PMID: 32861708
- Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways. | Xu, X., et al. 2020. Br J Pharmacol. 177: 5224-5245. PMID: 32964428
- The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway. | Liu, X., et al. 2021. Oxid Med Cell Longev. 2021: 5598980. PMID: 34336106
- Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation. | Li, H., et al. 2021. J Adv Res. 33: 241-251. PMID: 34603793
- Arctigenin inhibits abnormal germinal center reactions and attenuates murine lupus by inhibiting IFN-I pathway. | Zhang, X., et al. 2022. Eur J Pharmacol. 919: 174808. PMID: 35151645
- Arctigenin: pharmacology, total synthesis, and progress in structure modification. | Wu, D., et al. 2022. J Enzyme Inhib Med Chem. 37: 2452-2477. PMID: 36093586
- Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells. | Kang, KR., et al. 2022. Korean J Physiol Pharmacol. 26: 447-456. PMID: 36302620
- (-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. | Eich, E., et al. 1996. J Med Chem. 39: 86-95. PMID: 8568830
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arctigenin, 25 mg | sc-202957 | 25 mg | $83.00 |