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Arbutamine (CAS 128470-16-6)

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Alternate Names:
4-[(1R)-1-Hydroxy-2-[[4-(4-hydroxyphenyl)butyl]amino]ethyl]-1,2-benzenediol; (R)-4-[1-Hydroxy-2-[[4-(4-hydroxyphenyl)butyl]amino]ethyl]-1,2-benzenediol; (−)-Arbutamine
CAS Number:
128470-16-6
Molecular Weight:
317.38
Molecular Formula:
C18H23NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Arbutamine, a synthetic compound bearing structural resemblances to the natural catecholamines epinephrine and norepinephrine, plays a significant role in the elucidation of their physiological effects, particularly within the nervous system. By mimicking the action of these endogenous catecholamines, Arbutamine has become a pivotal tool in research focused on understanding the nuances of neuronal excitability, synaptic transmission, and neuronal plasticity. Its ability to replicate catecholamine stimulation allows scientists to delve into the complex processes governing the nervous system′s response to stress and stimuli, offering insights into how synaptic connections are strengthened or weakened in response to various factors.


Arbutamine (CAS 128470-16-6) References

  1. Pharmacologic stress echocardiography. Dobutamine and arbutamine stress testing.  |  Orsinelli, DA. and Daniels, CJ. 1999. Cardiol Clin. 17: 461-79, viii. PMID: 10453293
  2. Arbutamine stimulation detects viable myocardium 4 weeks after coronary occlusion.  |  Kisanuki, A., et al. 2001. J Am Soc Echocardiogr. 14: 138-48. PMID: 11174448
  3. Advances in Pharmacological Cardiac Stress Testing: Arbutamine Closed-Loop Feedback System.  |  Crouse, L. 1998. Echocardiography. 15: 393-400. PMID: 11175055
  4. Identification of viable myocardium early after acute myocardial infarction using closed-loop arbutamine echocardiography: comparison with positron emission tomography.  |  Pierard, LA., et al. 2001. Acta Cardiol. 56: 387-94. PMID: 11791807
  5. Effects of dobutamine and arbutamine on regional myocardial function in a porcine model of myocardial ischemia.  |  Hammond, HK. and McKirnan, MD. 1994. J Am Coll Cardiol. 23: 475-82. PMID: 8294703
  6. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent.  |  Nagarajan, R., et al. 1996. Cardiovasc Drugs Ther. 10: 31-8. PMID: 8723168
  7. Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing.  |  Abou-Mohamed, G., et al. 1996. Cardiovasc Drugs Ther. 10: 39-47. PMID: 8723169
  8. Clinical and diagnostic utility of arbutamine for cardiovascular stress testing during echocardiographic monitoring.  |  Armstrong, WF. and Bach, DS. 1995. Eur Heart J. 16 Suppl M: 24-7. PMID: 8869120
  9. [Whole body distribution of Tc-99m-sestamibi after pharmacological stress with arbutamine and dipyridamole compared with resting conditions].  |  Kotzerke, J., et al. 1997. Nuklearmedizin. 36: 19-22. PMID: 9082336
  10. Arbutamine stress echocardiography.  |  Ketteler, T., et al. 1997. Eur Heart J. 18 Suppl D: D24-30. PMID: 9183607
  11. Comparison of Tc-99m sestamibi perfusion imaging and echocardiography using an arbutamine infusion for the detection of coronary artery disease.  |  Hendel, RC., et al. 1997. Am J Cardiol. 79: 1518-21. PMID: 9185645
  12. Inotropic stress with arbutamine is superior to vasodilator stress with dipyridamole for the detection of reversible ischemia with Tc-99m sestamibi single-photon emission computed tomography.  |  Soman, P., et al. 1997. J Nucl Cardiol. 4: 364-71. PMID: 9362012
  13. A comparison of adenosine and arbutamine for myocardial perfusion imaging.  |  Anagnostopoulos, C., et al. 1998. Eur J Nucl Med. 25: 394-400. PMID: 9553169
  14. Hemodynamic effects of arbutamine.  |  Ogilby, JD., et al. 1998. Am J Cardiol. 82: 699-702, A9. PMID: 9732911
  15. Combined Tc-99m sestamibi first-pass radionuclide angiography and cardiac SPECT imaging during arbutamine infusion delivered by a computerized closed-loop system.  |  Borges-Neto, S., et al. 1999. Clin Nucl Med. 24: 42-7. PMID: 9890492

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Arbutamine, 10 mg

sc-481253
10 mg
$340.00