Arachidonoyl coenzyme A lithium salt (CAS 188174-63-2)

Arachidonoyl coenzyme A (CoA) lithium salt is an acyl-CoA derivative that plays a vital role in lipid metabolism and is a precursor for arachidonic acid-containing lipids. It is often used in research to study the metabolism of fatty acids and their incorporation into complex lipids, like phospholipids and triglycerides. As an intermediate in lipid biosynthesis, it can undergo enzymatic transformations by various acyltransferases and lipases, making it a crucial substrate in the synthesis of arachidonic acid-derived lipid mediators such as prostaglandins, thromboxanes, and leukotrienes. These lipid mediators significantly influence cellular signaling pathways, including inflammation, cell proliferation, and differentiation. In experimental settings, it serves as a substrate to investigate enzymatic activity in the formation of arachidonoyl-containing phospholipids, advancing our understanding of lipidomics and fatty acid metabolism. Researchers also use it to dissect the metabolic flux of polyunsaturated fatty acids and understand the regulatory networks that govern lipid processing. By doing so, scientists gain insights into how disruptions in lipid metabolism may contribute to various pathophysiological states, emphasizing the compound′s importance in basic biochemical and cell biology research focused on lipid homeostasis and metabolism.