Molecular structure of Arachidonoyl-AMC
Arachidonoyl-AMC
Alternate Names:
AAMCA
Application:
Arachidonoyl-AMC is a fluorogenic substrate for fatty acid amide hydrolase (FAAH)
Molecular Weight:
461.6
Molecular Formula:
C30H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Arachidonoyl-AMC is a fluorogenic substrate for fatty acid amide hydrolase (FAAH). This substrate is the basis for a simple, selective and sensitive assay for FAAH which is amenable to high-throughput screening.
Arachidonoyl-AMC References
- A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening. | Ramarao, MK., et al. 2005. Anal Biochem. 343: 143-51. PMID: 16018870
- A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase. | Kage, KL., et al. 2007. J Neurosci Methods. 161: 47-54. PMID: 17083980
- Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. | Montaser, R., et al. 2012. Chembiochem. 13: 2676-81. PMID: 23143757
- Prostaglandin ethanolamides attenuate damage in a human explant colitis model. | Nicotra, LL., et al. 2013. Prostaglandins Other Lipid Mediat. 100-101: 22-9. PMID: 23380599
- Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling. | Zhang, X. and Thayer, SA. 2018. Neuropharmacology. 128: 269-281. PMID: 29061509
- Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase. | Butler, CR., et al. 2017. J Med Chem. 60: 9860-9873. PMID: 29148769
- Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. | McAllister, LA., et al. 2018. J Med Chem. 61: 3008-3026. PMID: 29498843
- Scaffold hopping-guided design of some isatin based rigid analogs as fatty acid amide hydrolase inhibitors: Synthesis and evaluation. | Jaiswal, S., et al. 2018. Biomed Pharmacother. 107: 1611-1623. PMID: 30257379
- The endocannabinoid hydrolase FAAH is an allosteric enzyme. | Dainese, E., et al. 2020. Sci Rep. 10: 2292. PMID: 32041998
- Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. | Di Martino, S., et al. 2020. J Med Chem. 63: 3634-3664. PMID: 32176488
- Para-Aminobenzohydrazide Derivatives as Fatty Acid Amide Hydrolase Inhibitors: Design, Synthesis and Biological Evaluation. | Sedaghat, A., et al. 2020. Iran J Pharm Res. 19: 103-112. PMID: 33841526
- New Disulfiram Derivatives as MAGL-Selective Inhibitors. | Omran, Z. 2021. Molecules. 26: PMID: 34070869
- Discovery of Isatin-Based Carbohydrazones as Potential Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase. | Jaiswal, S. and Ayyannan, SR. 2022. ChemMedChem. 17: e202100559. PMID: 34637598
- A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network. | Cheng, R., et al. 2022. Acta Pharmacol Sin. 43: 3002-3010. PMID: 35513432
Substrate of:
Enzyme, FAAH, and Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arachidonoyl-AMC, 5 mg | sc-223784 | 5 mg | $180.00 | |||
Arachidonoyl-AMC, 25 mg | sc-223784A | 25 mg | $645.00 |