Arachidonic Acid-d8 CAS: 69254-37-1
MF: C20H24D8O2
MW: 312.5
An internal standard for the quantification of arachidonic acid.

Arachidonic Acid-d8 (CAS 69254-37-1)

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Application: An internal standard for the quantification of arachidonic acid
CAS Number: 69254-37-1
Molecular Weight: 312.5
Molecular Formula: C20H24D8O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. Intended for use as an internal standard for the quantification of arachidonic acid by GC- or LC-mass spectrometry. Arachidonic acid is an essential fatty acid and a precursor for all leukotrienes, prostaglandins, and thromboxanes. Almost all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-update of free arachidonate are all important aspects of cell signaling and inflammation.


References

1 Burgoyne, R.D., Morgan, A. The control of free arachidonic acid levels. Trends Biochem Sci 15 365-366 (1990). 2 Nixon, A.B., Greene, D.G., Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. Biochim Biophys Acta 1300 187-196 (1996).

Formulation :
A solution in methyl acetate
Physical State :
Liquid
Solubility :
Soluble in water (1.7 mg/ml at 25.0° C), ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), and 0.1M Na2CO3.
Storage :
Store at -20° C
Boiling Point :
57° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3246804
MDL Number :
MFCD00065888
SMILES :
[2H]/C(=C(\\[2H])/C/C(=C(/[2H])\\C/C(=C(/[2H])\\C/C(=C(/[2H])\\CCCC(=O)O)/[2H])/[2H])/[2H])/CCCCC

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Certificate of Analysis

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Arachidonic Acid-d8  Product Citations

See how others have used Arachidonic Acid-d8. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 17670936  Mukherjee, PK. et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 13152-13157.

Citations 1 to 1 of 1 total

What is the isotopic purity of your d8-arachidonic acid? Will it be >98% d8 or will it have d7. d6. d5, etc in it? Do you have this in stock?

Asked by: Jodi
Thank you for your question. The purity is referenced as ≥ 99% deuterated (d1-d8) and ≤ 1% d0. Please contact our Customer Care Department to inquire about current product availability. Please call us toll-free at (800) 457-3801 option 1, e-mail <[email protected]>, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-06-14
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