Contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. Intended for use as an internal standard for the quantification of arachidonic acid by GC- or LC-mass spectrometry. Arachidonic acid is an essential fatty acid and a precursor for all leukotrienes, prostaglandins, and thromboxanes. Almost all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-update of free arachidonate are all important aspects of cell signaling and inflammation.
1 Burgoyne, R.D., Morgan, A. The control of free arachidonic acid levels. Trends Biochem Sci 15 365-366 (1990). 2 Nixon, A.B., Greene, D.G., Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. Biochim Biophys Acta 1300 187-196 (1996).
A solution in methyl acetate
Soluble in water (1.7 mg/ml at 25.0° C), ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), and 0.1M Na2CO3.
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
What is the isotopic purity of your d8-arachidonic acid? Will it be >98% d8 or will it have d7. d6. d5, etc in it?
Do you have this in stock?
Asked by: Jodi
Thank you for your question. The purity is referenced as ≥ 99% deuterated (d1-d8) and ≤ 1% d0. Please contact our Customer Care Department to inquire about current product availability. Please call us toll-free at (800) 457-3801 option 1, e-mail <[email protected]>, or use the live chat on our website.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
You may not log in without verifying your email address. Please check your email (including your spam email) for the Welcome message that was sent.
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.
Already have an account?
Please check your email (including your spam email) for a Welcome message, and verify your email address to continue.