APRIN Antibody (2030D32a): sc-81635

APRIN Antibody (2030D32a) is a mouse monoclonal IgG1 antibody that detects APRIN protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-APRIN antibody (2030D32a) is available as the non-conjugated form. APRIN protein, also known as androgen-induced proliferation inhibitor, Androgen Shutoff 3 (AS3), or PDS5 regulator of cohesion maintenance homolog B (PDS5B), plays a crucial role in regulating androgen-dependent growth arrest in prostate cells, specifically mediating cell cycle arrest in the G0/G1 phase of prostate epithelial cells. This function helps prevent uncontrolled cell proliferation, which is a hallmark of cancer. Structurally, APRIN is a highly conserved protein characterized by a nuclear localization sequence near its C-terminal, a DNA-binding domain, a coiled coil domain, a leucine zipper, and a protein kinase domain, all contributing to regulatory functions within the cell. APRIN is predominantly expressed in smooth muscle stromal cells and both basal and luminal epithelial cells, where APRIN localizes to the nucleus, underscoring a role in transcriptional regulation. APRIN is related to fungal proteins such as Aspergillus bimD and Sodaria Spo76p, and APRIN loss has been strongly correlated with the development of prostate cancer, highlighting potential as a biomarker and therapeutic target in oncology.

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APRIN Antibody (2030D32a) References:

1. Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus.  |  Geck, P., et al. 1999. J Steroid Biochem Mol Biol. 68: 41-50. PMID: 10215036
2. Spo76p is a conserved chromosome morphogenesis protein that links the mitotic and meiotic programs.  |  van Heemst, D., et al. 1999. Cell. 98: 261-71. PMID: 10428037
3. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator.  |  Geck, P., et al. 2000. Proc Natl Acad Sci U S A. 97: 10185-90. PMID: 10963680
4. Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma.  |  Harada, H., et al. 2001. Int J Oncol. 18: 1003-7. PMID: 11295048
5. Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate.  |  Maffini, MV., et al. 2002. Endocrinology. 143: 2708-14. PMID: 12072405
6. Significant contribution of germline BRCA2 rearrangements in male breast cancer families.  |  Tournier, I., et al. 2004. Cancer Res. 64: 8143-7. PMID: 15548676
7. Exogenous fibroblast growth factors maintain viability, promote proliferation, and suppress GADD45alpha and GAS6 transcript content of prostate cancer cells genetically modified to lack endogenous FGF-2.  |  Shain, SA. 2004. Mol Cancer Res. 2: 653-61. PMID: 15561781
8. Androgen receptor signaling and vitamin D receptor action in prostate cancer cells.  |  Murthy, S., et al. 2005. Prostate. 64: 362-72. PMID: 15754350
9. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.  |  Rankin, S., et al. 2005. Mol Cell. 18: 185-200. PMID: 15837422

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-APRIN Antibody (2030D32a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-APRIN Antibody (2030D32a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

APRIN Antibody (2030D32a) Specifications

Alternate Product Name: APRIN

Product Clone Name: 2030D32a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: APRIN

Epitope Species: human

Product Reactivity/Detection: APRIN

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for APRIN Antibody (2030D32a): N/A

The preferred antibody is Antibody (): .