APRIL Antibody (H-10): sc-374674

APRIL Antibody (H-10) is a mouse monoclonal IgG2a antibody that detects APRIL in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). APRIL, also known as TNFSF13, is a Type II membrane protein that plays a pivotal role in various biological processes, including immune response regulation and tissue homeostasis. APRIL (H-10) antibody enables detection in transformed cell lines and human tumor tissues, particularly in colon, thyroid, and lymphoid systems, highlighting APRIL′s significance in cancer biology. The structure of APRIL features a C-terminal extracellular domain with jelly roll topology, crucial for ligand trimerization. This structural feature facilitates APRIL binding to receptors, leading to oligomerization that triggers downstream signaling pathways essential for cell proliferation and survival. APRIL′s ability to form multivalent ligands at the receptor binding site enhances functional capacity, making anti-APRIL antibody (H-10) an invaluable tool for investigating complex roles in health and disease.

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APRIL Antibody (H-10) References:

1. A proliferation-inducing ligand (APRIL) is expressed by astrocytes and is increased in multiple sclerosis.  |  Thangarajh, M., et al. 2007. Scand J Immunol. 65: 92-8. PMID: 17212772
2. Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients.  |  Roderburg, C., et al. 2013. J Crit Care. 28: 882.e1-11. PMID: 23337484
3. The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis.  |  Zhao, J., et al. 2014. Scand J Rheumatol. 43: 462-9. PMID: 24898359
4. B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells.  |  Gorbacheva, V., et al. 2015. Am J Transplant. 15: 346-57. PMID: 25496308
5. Pathogenic Role of a Proliferation-Inducing Ligand (APRIL) in Murine IgA Nephropathy.  |  Kim, YG., et al. 2015. PLoS One. 10: e0137044. PMID: 26348210
6. Urinary B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL): potential biomarkers of active lupus nephritis.  |  Phatak, S., et al. 2017. Clin Exp Immunol. 187: 376-382. PMID: 27804111
7. Abundant a proliferation-inducing ligand (APRIL)-producing macrophages contribute to plasma cell accumulation in immunoglobulin G4-related disease.  |  Kawakami, T., et al. 2019. Nephrol Dial Transplant. 34: 960-969. PMID: 30325430
8. APRIL and BAFF play a key role in differentiating vitreoretinal lymphoma from uveitis.  |  Tian, S., et al. 2022. Clin Chim Acta. 535: 1-6. PMID: 35820532
9. Serum BAFF (B-cell activating factor) and APRIL (a proliferation-inducing ligand) levels in the first trimester may predict the future development of gestational diabetes mellitus.  |  Banerjeee, S., et al. 2024. Diabetes Metab Syndr. 18: 103019. PMID: 38653036
10. Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody-producing cells in different tissues.  |  Eslami, M., et al. 2024. Proc Natl Acad Sci U S A. 121: e2404309121. PMID: 38990948

The preferred APRIL antibody is APRIL Antibody (F-5): sc-374673.