Molecular structure of Apramycin sulfate, CAS Number: 65710-07-8
Apramycin sulfate (CAS 65710-07-8)
Alternate Names:
Nebramycin II
Application:
Apramycin sulfate is an antibiotic that blocks protein synthesis translocation
CAS Number:
65710-07-8
Molecular Weight:
539.58 (free base)
Molecular Formula:
C21H41N5O11•xH2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Apramycin Sulfate is an aminoglycoside antibiotic frequently utilized in research applications to study bacterial protein synthesis and the mechanisms of antibiotic resistance. In molecular biology, it is employed to probe the specificity and inhibition of ribosomal function, as it binds to the bacterial 16S rRNA, disrupting the process of translation. This compound is also pivotal in analyzing the genetic mutations that confer resistance to aminoglycosides, providing insights into evolutionary processes that bacteria employ to circumvent antibiotic action. Additionally, Apramycin Sulfate serves as a reference substance in the development of diagnostic assays that detect aminoglycoside-modifying enzymes, which are key markers of resistance in pathogenic bacteria.
Apramycin sulfate (CAS 65710-07-8) References
- Involvement of a cytochrome P450 monooxygenase in thaxtomin A biosynthesis by Streptomyces acidiscabies. | Healy, FG., et al. 2002. J Bacteriol. 184: 2019-29. PMID: 11889110
- Characterization of resistance patterns and detection of apramycin resistance genes in Escherichia coli isolated from swine exposed to various environmental conditions. | Mathew, AG., et al. 2003. Int J Food Microbiol. 89: 11-20. PMID: 14580969
- Effect of antibiotics on growth and laccase production from Cyathus bulleri and Pycnoporus cinnabarinus. | Dhawan, S., et al. 2005. Bioresour Technol. 96: 1415-8. PMID: 15792590
- Predicting the long-term toxicity of five-antibiotic mixtures to Vibrio qinghaiensis sp. Q67. | Zhang, J. and Chen, Q. 2014. Pak J Pharm Sci. 27: 1605-9. PMID: 25262505
- A sensitive non-derivatization method for apramycin and impurities analysis using hydrophilic interaction liquid chromatography and charged aerosol detection. | Long, Z., et al. 2016. Talanta. 146: 423-9. PMID: 26695285
- Simple spectrofluorimetric methods for determination of veterinary antibiotic drug (apramycin sulfate) in pharmaceutical preparations and milk samples. | Mabrouk, MM., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 224: 117395. PMID: 31362184
- Development of a gene expression system for the uncommon actinomycete Actinoplanes rectilineatus NRRL B-16090. | Yushchuk, O., et al. 2020. J Appl Genet. 61: 141-149. PMID: 31912451
- Antibiotic-free extended boar semen preserved under low temperature maintains acceptable in-vitro sperm quality and reduces bacterial load. | Menezes, TA., et al. 2020. Theriogenology. 149: 131-138. PMID: 32259750
- Novel Eco-friendly HPLC Methods Using Refractive Index Detector for Analysis of Three Veterinary Antibiotics in Pharmaceutical Formulations and Rat Plasma. | Gamal, M. and Elhalim, LMA. 2020. J Chromatogr Sci. 58: 940-950. PMID: 32901249
- Research Note: The effect of a probiotic E. faecium 669 mitigating Salmonella Enteritidis colonization of broiler chickens by improved gut integrity. | Olsen, MSR., et al. 2022. Poult Sci. 101: 102029. PMID: 35944375
- [Subchronic toxicity of apramycin in pigs]. | Pashov, D., et al. 1987. Vet Med Nauki. 24: 37-42. PMID: 3672917
- Growth performance and intestinal microbial populations of growing pigs fed diets containing sucrose thermal oligosaccharide caramel. | Orban, JI., et al. 1997. J Anim Sci. 75: 170-5. PMID: 9027562
Inhibitor of:
Ribosomal Protein S7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apramycin sulfate, 1 g | sc-210832 | 1 g | $61.00 | |||
Apramycin sulfate, 5 g | sc-210832A | 5 g | $101.00 | |||
Apramycin sulfate, 25 g | sc-210832B | 25 g | $500.00 |