Molecular structure of Apoptosis Activator VII, Apoptozole, CAS Number: 1054543-47-3
Apoptosis Activator VII, Apoptozole (CAS 1054543-47-3)
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Application:
Apoptosis Activator VII, Apoptozole is a cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70
CAS Number:
1054543-47-3
Purity:
≥99%
Molecular Weight:
625.6
Molecular Formula:
C33H25F6N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 µM).
Apoptosis Activator VII, Apoptozole (CAS 1054543-47-3) References
- An apoptosis-inducing small molecule that binds to heat shock protein 70. | Williams, DR., et al. 2008. Angew Chem Int Ed Engl. 47: 7466-9. PMID: 18729127
- Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition. | Evans, LE., et al. 2015. PLoS One. 10: e0140006. PMID: 26458144
- Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms. | Park, SH., et al. 2018. Cell Chem Biol. 25: 1242-1254.e8. PMID: 30057298
- L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70. | Luo, LL., et al. 2019. CNS Neurosci Ther. 25: 1030-1041. PMID: 31218845
- Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections. | Yang, J., et al. 2020. ACS Infect Dis. 6: 832-843. PMID: 31967789
- Synthesis of an Hsp70 inhibitor and its assessment of lysosomal membrane permeabilization. | Park, SH., et al. 2021. STAR Protoc. 2: 100349. PMID: 33665629
- SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling. | Liu, H., et al. 2021. Theranostics. 11: 4187-4206. PMID: 33754056
- A triple-targeting delivery system carrying two anticancer agents. | Li, H., et al. 2021. Org Biomol Chem. 19: 8009-8013. PMID: 34236071
- Cytoplasmic Hsp70s promote EcR transport into the nucleus by responding to various stimuli. | Gu, J., et al. 2023. Insect Biochem Mol Biol. 157: 103964. PMID: 37230333
- An engineered nanoplatform inhibiting energy metabolism and lysosomal activity of tumor cells to multiply cisplatin-based chemotherapy. | Jiang, W., et al. 2023. Biomaterials. 302: 122354. PMID: 37879187
Inhibitor of:
caspase-5, CDSN, HSC 70, HSP 70, LOC440335, Pdcd-7, Programmed cell death (PDCD), and Ssa1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apoptosis Activator VII, Apoptozole, 10 mg | sc-221257 | 10 mg | $238.00 |