Molecular structure of Apoptosis Activator 2, CAS Number: 79183-19-0
Apoptosis Activator 2 (CAS 79183-19-0)
See product citations (2)
Application:
Apoptosis Activator 2 is an indoledione caspase activator
CAS Number:
79183-19-0
Purity:
>95%
Molecular Weight:
306.1
Molecular Formula:
C15H9Cl2NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 muM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3.
Apoptosis Activator 2 (CAS 79183-19-0) References
- Direct activation of the apoptosis machinery as a mechanism to target cancer cells. | Nguyen, JT. and Wells, JA. 2003. Proc Natl Acad Sci U S A. 100: 7533-8. PMID: 12808146
- Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. | Alavian, KN., et al. 2009. Neural Dev. 4: 11. PMID: 19291307
- Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody. | Farivar, TN., et al. 2012. N Am J Med Sci. 4: 582-5. PMID: 23181231
- Chemotherapy agents-induced immunoresistance in lung cancer cells could be reversed by trop-2 inhibition in vitro and in vivo by interaction with MAPK signaling pathway. | Wang, X., et al. 2013. Cancer Biol Ther. 14: 1123-32. PMID: 24025415
- Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. | Cui, Z., et al. 2014. Mol Cell Biol. 34: 96-109. PMID: 24164898
- Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. | Shvartsur, A. and Bonavida, B. 2015. Genes Cancer. 6: 84-105. PMID: 26000093
- Glucosidase II beta subunit (GluIIβ) plays a role in autophagy and apoptosis regulation in lung carcinoma cells in a p53-dependent manner. | Khaodee, W., et al. 2017. Cell Oncol (Dordr). 40: 579-591. PMID: 28929344
- Upregulation of caspase-3 by high glucose in chondrocyte involves the cytoskeleton aggregation. | Hua, L., et al. 2020. Eur Rev Med Pharmacol Sci. 24: 5925-5932. PMID: 32572905
- Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. | Zheng, Y., et al. 2021. Aging (Albany NY). 13: 7096-7119. PMID: 33639613
- The Crosstalk between Autophagy and Apoptosis Is Necessary for Myogenic Differentiation. | Jiang, A., et al. 2021. J Agric Food Chem. 69: 3942-3951. PMID: 33755473
- Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA. | Ma, Y., et al. 2021. Sci Rep. 11: 13471. PMID: 34188113
- Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression. | Abou Zeid, LY., et al. 2022. Cell Stress Chaperones. 27: 11-25. PMID: 34719748
- Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold. | Krymov, SK., et al. 2022. Eur J Med Chem. 228: 113997. PMID: 34902732
- Concomitant pyroptotic and apoptotic cell death triggered in macrophages infected by Zika virus. | Wen, C., et al. 2022. PLoS One. 17: e0257408. PMID: 35446851
- A literature review of the promising future of TROP2: a potential drug therapy target. | Wen, Y., et al. 2022. Ann Transl Med. 10: 1403. PMID: 36660684
Inhibitor of:
HAX-1.Activator of:
caspase-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apoptosis Activator 2, 5 mg | sc-202956 | 5 mg | $92.00 |